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. 2015 Oct 5;19(2):pyv115. doi: 10.1093/ijnp/pyv115

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 8. — Adeno-associated virus (AAV)-Cre–mediated leptin receptor (LepRb) deletion in the ventral tegmental area (VTA) results in anxiogenic-like behaviors. (A) Timeline of experimental procedures and behavioral tests. (B) Elevated plus-maze test. Left, percent open arm entries; middle, percent open arm time; right, number of total entries. n = 13 to 15 each group. (C) Light-dark box test. Left, latency to enter the light side; middle, time spent in the light compartment; right, number of transitions between light and dark compartments. n = 12 to 14 each group. (D) Novelty suppressed feeding test. Left, latency to feed; right, home-cage food consumption within 5 minutes immediately after the test. n = 12 to 15 each group. (E) Body weight before or after AAV injection. n = 10 to 13 each group. *P < .05; **P < .01 compared with the AAV-GFP control group.