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. 2016 Feb 19;8(3):247–267. doi: 10.15252/emmm.201505748

Figure 4. ABCB8 transgenic mice have less cell death and better cardiac function after I/R injury.

Figure 4

  1. Cardiac function in ABCB8 NTG and TG mice undergoing sham or I/R procedure. ANOVA followed by post hoc Tukey's test was performed for each time point. *P < 0.05 compared with TG‐sham at the same time point. $ P < 0.05 compared with NTG‐I/R at the same time point. § P < 0.05 compared with NTG‐sham at the same time point. N = 5 mice for NTG‐sham and NTG‐I/R and N = 6 mice for TG‐sham and TG‐I/R. Exact P‐values are included in Appendix Table S3.
  2. Representative images of TUNEL staining for mice with the indicated genotype undergone the indicated procedure. Scale bar, 100 μm.
  3. Quantification of apoptosis in ABCB8 TG and NTG mice with the indicated procedure. ANOVA followed by post hoc Tukey's test was performed. *P = 0.035. N = 4 mice for TG‐I/R and N = 6 mice for all other groups.
  4. Nppa expression in mice subjected to sham or I/R procedure. ANOVA followed by post hoc Tukey's test was performed. *P = 3.24E‐4 NTG‐sham vs. NTG‐I/R. *P = 0.002 TG‐sham vs. TG‐I/R. *P = 8E‐6 NTG‐I/R vs. TG‐I/R. N = 5 mice for NTG‐sham and NTG‐I/R and N = 6 mice for TG‐sham and TG‐I/R.
  5. Nppb expression in mice subjected to sham or I/R procedure. ANOVA followed by post hoc Tukey's test was performed. *P < 1E‐8 NTG‐sham vs. NTG‐I/R. *P = 0.032 NTG‐I/R vs. TG‐I/R. N = 5 mice for NTG‐sham and NTG‐I/R and N = 6 mice for TG‐sham and TG‐I/R.
  6. Myh7 expression in mice subjected to sham or I/R procedure. ANOVA followed by post hoc Tukey's test was performed. *P = 0.04 NTG‐sham vs. NTG‐I/R. *P = 0.034 NTG‐I/R vs. TG‐I/R. N = 5 mice for NTG‐sham and NTG‐I/R and N = 6 mice for TG‐sham and TG‐I/R.
Data information: All data are expressed as mean ± SEM. N.S., not significant.