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. 2016 Feb 19;8(3):247–267. doi: 10.15252/emmm.201505748

Figure 5. ABCB8 transgenic mice demonstrate reduced acute cellular injury and decreased left ventricular fibrosis and cardiac stress 28 days after injury.

Figure 5

  1. Representative H&E staining of peri‐infarct area demonstrated reduced cellular injury in ABCB8 TG mice after I/R. Scale bar, 115 μm.
  2. Representative H&E and Masson's trichrome (MT) staining in mouse heart 28 days after the indicated procedure. Scale bar, 1,100 μm.
  3. Quantification of tissue fibrosis in ABCB8 NTG and TG mice subjected to I/R. *P = 0.047 with two‐tailed unpaired t‐test. Two to three sections from each mice were quantified; N = 4 mice for NTG and N = 6 mice for TG.
  4. Nppa expression in mice subjected to sham or I/R procedure. ANOVA followed by post hoc Tukey's test was performed. *P = 0.006 NTG‐sham vs. NTG‐I/R. *P = 0.015 NTG‐I/R vs. TG‐I/R. N = 5 mice for NTG‐sham and TG‐I/R, N = 6 mice for TG‐sham, and N = 4 mice for NTG‐I/R.
  5. Nppb expression in mice subjected to sham or I/R procedure. ANOVA followed by post hoc Tukey's test was performed. *P = 0.001 NTG‐sham vs. NTG‐I/R. *P = 0.004 NTG‐I/R vs. TG‐I/R. N = 5 mice for NTG‐sham and TG‐I/R, N = 6 mice for TG‐sham, and N = 4 mice for NTG‐I/R.
  6. Myh7 expression in mice subjected to sham or I/R procedure. ANOVA followed by post hoc Tukey's test was performed. *P = 0.002 NTG‐sham vs. NTG‐I/R. *P = 0.011 NTG‐I/R vs. TG‐I/R. N = 5 mice for NTG‐sham and TG‐I/R, N = 6 mice for TG‐sham, and N = 4 mice for NTG‐I/R.
Data information: All data are expressed as mean ± SEM. N.S., not significant.