Table 2.
Bone Microarchitecture Parameters 1 Month After Sham Operation or VBX (μCT Measurements) in Control, β−/−, or β2.3col1−/− Mice
| β2AR−/− mice | β2AR+/+ PBS | β2AR+/+ VBX | β2AR−/− PBS | β2AR−/− VBX |
|---|---|---|---|---|
| Tb.N | 3.900±0.269 | 3.834±0.144 | 4.099±0.356 | 3.827±0.231 |
| Tb.Th (mm) | 0.032±0.002 | 0.028±0.002* | 0.032±0.002 | 0.032±0.002 |
| Tb.Sp (mm) | 0.259±0.019 | 0.258±0.016 | 0.245±0.022 | 0.265±0.016 |
| Ob.S/BS (%) | 16.313±1.334 | 10.222±1.394*** | 15.510±1.195 | 16.128±0.835 |
| Oc.S/BS (%) | 2.293±0.517 | 4.645±0.923*** | 2.292±0.461 | 2.275±0.641 |
| N.Ob/B.Pm (Nb/mm) | 9.560±0.152 | 5.422±0.178*** | 9.743±0.182 | 2.292±0.461 |
| N.Oc/B.Pm (Nb/mm) | 2.151±0.685 | 5.034±1.713** | 2.197±1.145 | 2.700±1.390 |
| MS/BS (%) | 45.535±6.999 | 26.075±6.840* | 46.204±7.210 | 45.871±6.544 |
| βBFR/BS (μm3/μm2/d) | 1.055±0.082 | 0.6135±0.424* | 1.105±0.076 | 1.092±0.0875 |
| MAR (μm/d) | 2.317±0.331 | 2.353±0.379 | 2.392±0.283 | 2.382±0.443 |
| β2AR2.3col1−/− mice | β2AR2.3col1+/+ PBS | β2AR2.3col1+/+ VBX | β2AR2.3col1−/− PBS | β2AR2.3col1−/− VBX |
| Tb.N | 4.237±0.243 | 4.133±0.254 | 4.402±0.063 | 4.464±0.332 |
| Tb.Th (mm) | 0.040±0.003 | 0.036±0.001* | 0.040±0.003 | 0.040±0.003 |
| Tb.Sp (mm) | 0.231±0.018 | 0.251±0.026 | 0.226±0.005 | 0.222±0.028 |
| Ob.S/BS (%) | 16.874±0.835 | 10.623±1.682*** | 16.622±1.070 | 16.542±1.310 |
| Oc.S/BS (%) | 2.252±0.707 | 5.258±1.389*** | 2.375±1.061 | 2.756±1.282 |
| N.Ob/B.Pm (Nb/mm) | 9.871±1.246 | 5.625±0.744*** | 9.623±1.401 | 9.520±1.773 |
| N.Oc/B.Pm (Nb/mm) | 2.162±0.723 | 5.320±1.581** | 2.288±1.137 | 2.835±1.342 |
| MS/BS (%) | 46.472±7.436 | 27.429±7.035* | 46.774±6.860 | 45.873±7.280 |
| βBFR/BS (μm3/μm2/d) | 1.098±0.084 | 0.655±0.418* | 1.112±0.074 | 1.097±0.0827 |
| MAR (μm/d) | 2.363±0.367 | 2.388±0.402 | 2.378±0.362 | 2.392±0.381 |
Tb.N, trabeculae number; Tb.Th, trabeculae thickness; Tb.Sp, trabeculae space; Ob.S/BS, osteoblast surface per bone surface; Oc.S/BS, osteoclast surface per bone surface; N.Ob/B.Pm, osteoblasts number per bone perimeter; N.Oc/B.Pm, osteoclasts number per bone perimeter; MS/BS, mineralized surface per bone surface; BFR/BS, bone formation rate per bone surface; MAR, mineral apposition rate. n = 10/group; mean±standard deviations.
*
p < 0.05,
**
p < 0.01,
***
p < 0.005 versus control.