Table 4.
The top functions of genes with an altered expression pattern in vitiligo patients’ PBMCs
| Molecules in network | Score | Focus molecules | Top functions |
|---|---|---|---|
| ADRM1, AKT1S1, Ant, CORO1A, CYC1, DOK3, EDA, INO80E, KSR2, MAGEC1, MIB2, MICAL1, NCF1C, NFkB (complex), NFKBID, NMRAL1, PAM16 (includes EG:100042179), PIDD, PKN3, RAB1B, RUSC2, RUVBL2, SLC2A6, SPATA20, ST18, ST6GALNAC4, TELO2, TIMM13, TIMM17B, TNFRSF10C, TSPO, UQCRC1, VDAC2, WDR34, ZNHIT2 | 50 | 33 | Cell cycle, connective tissue disorders, dental disease |
| ABTB1, APBA3, ATP13A2, C1QA, C1QB, CA1, CCS, CD320, CFD, CLEC10A, creatine kinase, CTSD, DBF4 (includes EG:10926), DDAH2, DYSF, EGLN2, Ferritin, FTL, HBA1/HBA2, HBB, hemoglobin, LRWD1, MCM2, MYL4, MZF1, NFE2, PAPPA, PRDX2, SCAND1, SERPINF2, SIGLEC1, TBKBP1, TMSB10/TMSB4X, TNFRSF6B, Vegf | 43 | 31 | Protein synthesis, hematological disease, hereditary disorder |
| AES, AGTRAP, ASGR1, BCAT2, CSK, Eif4g, ERK, ETS, FAU, FERMT3, GP9, GP1BB, HK3, IL23R, ITGA2B, LIME1, Mac1, MATK, MBD3 (includes EG:17192), MVP, Ribosomal 40s subunit, RNF181, Rnr, RPS9, RPS10, RPS11, RPS16, RPS19, RPS26, RPS15A, SRCIN1, TRAF, USF2, ZBTB17, ZGPAT | 38 | 28 | Developmental disorder, hematological disease, hereditary disorder |
| ADAM15, ARHGAP4, c-Src, CAMK1, CLCF1, CYBA, Cyba-Ncf1c-Ncf2-Nox-Ncf4, EFNB2, ERK1/2, G6PC3, HMMR, IgG2b, IgG2c, KLRC1, MTUS1, NCF1, NCF4, NOXA1, Phox, RAB4B, Rap1, Rap1-gp91-p22 phox-p40 phox-p47 phox-p67 phox, RASGRP4, RGS14, RIN1, RRAS, SCRIB, SHARPIN, SIPA1, SORBS2, SYTL1, TMEM176B, TXN2, TYMP, VEGFB | 35 | 27 | Hereditary disorder, inflammatory disease, free radical scavenging |
| Akt, C12orf44, CD19, CD22, CD79A, CD79B, CDON, COL6A2, COLEC12, Collagen Type VI, FCGRT, HCST, IgD, IgG1, Igg3, IgG2a, INPP5E, KLKB1, LGALS3BP, MARCO, mir-26, mir-29, mir-221, MIR17HG, PFKL, Ppp2c, PPP2R5B, PVRL2, PVRL3, SCAVENGER RECEPTOR CLASS A, SPHK2, Sphk, TCL1A, TNFRSF13C, TYROBP | 32 | 26 | Cell death and survival, cellular development, hematological system development and function |
| ABCD1, adenosine-tetraphosphatase, APEX2, ATP5D, ATP5G1, ATP5I, ATP6V0D1, ATPase, BLVRB, CARNS1, CD40, DQX1, EVI5L, FBL, FCER2, FCRLA, H+-transporting two-sector ATPase, Iga, IgG, Igm, IL12 (complex), Immunoglobulin, JINK1/2, LILRB3, LST1, MHC Class II (complex), NAT14, NINL, NUDT18, RABAC1, SMOX, SYP, TCIRG1, TRAF2, UBXN11 | 31 | 25 | Energy production, nucleic acid metabolism, small molecule biochemistry |
| Actin, ADAM8, Alpha Actinin, Alpha catenin, Cadherin, Calcineurin protein(s), Calmodulin, CAMK2B, CBWD2, CDC42EP2, CORO6, CORO2B, CPNE5, DCTN6, DVL1, F Actin, FKBP8, Gamma tubulin, KCNN4, KLF5, LYPLA2, MARK4, MYL9, Myosin, ORAI1, OSCAR, PARVB, PDLIM7, PITPNM1, PLEC, PPP1R12C, RHOC, Rock, S100A9, TMOD1 | 31 | 25 | Cell morphology, cellular assembly and organization, cellular function and maintenance |
| Acox, Alp, AMPK, CAPN10, CCDC99, CDC34, Cdk, CORO7/CORO7-PAM16, Cyclin A, Cyclin D, Cyclin E, EIF4E, FADS2, FGF9, FRMD6, GADD45GIP1, Insulin, mir-30, mir-130, mir-181, mir-368, MTORC1, PNKP, POLD1, POP7 (includes EG:100004610), RASSF8, Rb, RPPH1, SLC30A10, SLC6A8, STARD10, STK11, TFEB, TOB1, TUBE1 | 31 | 25 | Endocrine system disorders, reproductive system disease connective tissue disorders |
| AATK, Adaptor protein 1, alcohol group acceptor phosphotransferase, Casein, Caspase 3/7, CDC37, CDK5, DIXDC1, ECSIT, GCDH, GRK6, GZMH, Ikk (family), IL-1R, IL1R2, IRAK1, IRAK, IRF, IRS, Jnk, LLGL2, LONP1, MAP2K2, MAP3K10, MAP3K11, MAP3K, mir-199, NEFH, NEFL, PAWR, PKN1, PPP5C, SIGIRR, SPSB2, TRAF7 | 28 | 24 | Cell-to-cell signaling and interaction, cellular assembly and organization, cellular function and maintenance |
| ABCC9, ACD, ARL4A, BATF, Cbp/p300, CDA, COBRA1, EDF1, FKBP14, GAPDH, HDAC10, HIST1H3A (includes others), HIST1H4A (includes others), HISTONE, Histone h4, Holo RNA polymerase II, IFI35, IFI27L2, IFITM2, IFN ALPHA RECEPTOR, IFN alpha/beta, Ifnar, Importin alpha, Interferon-alpha induced, MED16, mediator, MX1, POLR2E, PPARG, PRMT1, RNA polymerase II, SSBP4, TERC, THAP7, ZBTB7B | 28 | 24 | Cellular assembly and organization, cardiovascular system development and function, cellular function and maintenance |
| 60S ribosomal subunit, ADAMTS1, Ap1, C1q, Cg, CK1, Creb, DSCC1, FGF2, Fibrinogen, GAS1 (includes EG:14451), glutathione peroxidase, glutathione transferase, GPX1 (includes EG:14775), GST, GSTM3, GSTP1, GSTZ1, KLHL4, KPTN, Laminin, Mek, mir-23, NKG7, PTX3, RPL3, RPL8, RPL18, RPL23, RPL24, RPL18A, RPL37A, RPL7A, SPI1 (includes EG:20375), TNFRSF8 | 28 | 23 | Drug metabolism, protein synthesis, cardiovascular system development and function |
| ARHGEF10L, CD3-TCR, CTDSP1, DHX58, DLEU1, DNASE2, DRAP1, E2f, GAS2L1, Hat, HIST1H2BJ/HIST1H2BK, HLA Class I, HLA-A, Hla-abc, HLA-G, HLA-J, IFN TYPE 1, IMPA2, IRF7, LILRA5, MHC, MHC CLASS I (family), Nc2, NCLN, NFAT (complex), NFkB (family), NLRP12, NOMO1 (includes others), OAS1, PSMB10, Ras, RFXANK, SLC25A22, SPCS2, TNFRSF14 | 27 | 23 | Dermatological diseases and conditions, immunological disease, inflammatory disease |
The first 12 functional groups are presented, altogether 21 groups were found.