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. 2016 Mar 1;11(3):e0150636. doi: 10.1371/journal.pone.0150636

Fig 4. Effects of PKA and CaMKII inhibitors on PM-LTP.

Fig 4

(A, B,C) Time course change of the eIPSC amplitudes in experiments where ATP (100 μM) was applied after treatments with PKA inhibitors, H-89 (A) and cAMPS-Rp (B), and a CaMKII inhibitor, KN-62 (C). Inset shows representative averaged traces of eIPSC recorded before (thin line) and after ATP application (thick line). (D) Effects of PKA and CaMKII inhibitors on the mean amplitudes of eIPSCs recorded during the periods10 to 15 min after ATP application. (E) Effects PKA and CaMKII inhibitors on the mean values of changes in the number of functioning GABAA receptors (N) and the size of unitary current through the GABAA receptor (i). Filled bars (ATP) indicate the values obtained after application of ATP alone (data taken from Figs 2B and 3C). Asterisk indicates a level of statistically significant difference (*: p<0.05, **: p<0.01, N.S.: no significant difference).