Table 6.

THC-dependent decrease or increase in miR expression in the striatum during acute-SIV infection. miR names, validated or predicted target genes are shown.

	miRs	Target genes
Decreased miR expression due to THC/SIV compared to VEH/SIV	mml-miR-338-5p _R-1	PHC3, SCN9A, HEMGN, KLF2, CUL2, KIAA1370, ESRRG, GOLT1B, GYPA, INTU, TSHZ1, USP25, PCDH20, MSTN, GTPBP10, SMAD5, HESX1, RORA, DLGAP1, GUCY1A3, RAB28, DDX59, RABGGTB, DSC3, TRAT1, COPS2, CDH12, ATP6V0A4, GRINL1A, GCOM1, ADM, DCLRE1B, UBA5, UFM1, KRTAP4-8, PABPC4L, WDR72, C1orf96, TNPO1, KRTAP4-11, ETS1, AIMP1, STAU2, IL6, GALNT7, C14orf28, FIGNL2, LIN28B, TRIM71, IGDCC3, ARID3B, STARD9, PTAFR, THRSP, PRR23A, SMARCAD1, YOD1, FIGN, TTLL4, PRTG, C9orf40, C18orf21, SERF2, KCTD21, PXT1, ARHGEF38, DNA2, ZBP1, TGFBR1, RPL36A, SLC5A9, CYP4F2, BRWD1, GDF6, COIL, SIGLEC14, XKR8, LRIG3, NPHP3, MRS2, ZCCHC9, SYNC, SLC35D2, ACVR1C, LRIG2, BZW1, GNPTAB, NDUFA4, CDC34, ZNF322A, THAP9, HIF1AN, ADRB2, DDX19B, DDX19A, ESR2, GALNT1, DDI2, SMC1A, MAP4K3, ERCC6, ABT1, PGRMC1, PARS2, DTX2, MED28, HIC2, ZNF583, KCNJ11, ARG2, PPP1R15B, GATM, CCNJ, KIAA1429, DDTL, CPEB1,HAND1, KHNYN, ATPAF1, LIPT2, BRF2, IGF1R, RPUSD3, DCLRE1B, ZNF215, ZNF341, CNTRL, FMO4, GPCPD1, C8orf58, GJC1, POLR2D, MED8, FAM103A1, OPA3, SFMBT1, FRAS1, CDC25A, RNF170, DVL3, UHRF2, NAP1L1, ZNF347, MYO1H, STX3, APBB3, COL1A2, TMEM2, PPAPDC1B, LHCGR, IGF2BP2, ADAMTS8, SPRYD7, ATG10, DPH3, STARD13, CASP3, SEMA4F, SERPINB9, CLCN5, PLCB2, IGF2BP1, CCNF, SRD5A3, ZNF587, DOK3, ZNF792, TGFBR3, MAP3K1, FNDC3A, ZNF10, ZNF763, CCL7, POM121L12, ACSL6, SIGLEC5, ZFYVE26, ZNF197, LIMD2, SNX6, MAPK6, C5orf62, AHCTF1, HDX, ADAMTS15, KIAA1274, IGSF1, CD200R1, CCDC76, POLQ, STAG3, IL22RA1, PUS7L, RANBP2, TSEN34, ZNF200, MSR1, MARS2, ZNF343, QARS, CD59, TXNDC6, TMEM234, COL3A1, AMACR, GEMIN7, GXYLT1, CPA4, OLFM4, USP12, PLEKHG6, CCR7, SUB1, RBM19, TMEM144, FNDC9, SCN11A, PLA2G2F, BEGAIN, TBKBP1, UFM1, ZNF417, FAM20A, TTC31, ZNF202, RRM2, SDR42E1, TNFSF9, PLXND1, KLHDC8B, HIF3A, LSM11, PLA2G3, UTRN, SSX5, RMI2, SMUG1, DPP3, BTN2A1, ARHGAP28, NEK3, CTPS2, SSX4, CDK6, CDC25A, MYC, BCL2, NKIRAS2, ITGB3, NF2, NRAS, KRAS, PRDM1, LIN41, TRIM71, FOXA1, NR1I2, VDR, RAVER2, HMGA2, HMGA1, EIF2C4, APP, E2F1, WECH, UHRF2, DICER1, HRAS, IGF2, LIN28A, NFKB1, ZFP36L1
	mml-let-7a-5p
	hsa-miR-151b_R+3	WNT1, SEZ6L, NTRK2, N4BP1, PHF15, CASZ1, WIPI2, SOX12, RIMBP2, SLC12A5, BDNF, NLK, GATA6, CDX2, PLAG1, HOXA11, BCL2, PROX1, KAT2B, CDKN1B, ZNF763, DDIT4, ATM, HIPK2, BCL2L11, HRAS, RNF2, RALA, SIRT1, PRAP1, DUSP6, PTPN11, DUSP5, PTPN22, FOS, MTMR3, KLF6, MCL1, XIAP, GPR78,
	hsa-miR-181a-2-3p	ZNF781, ZNF439, ZNF594, ZNF780B, OSBPL3, PRTG, ZNF780A, RAB3IP, KIAA0528, TMEM87B, PPIP5K2, ATM, NUDT12, FIGN, IL2, FBXO34, TGFBRAP1, TRDMT1, TRIM2, TMEM131, KIAA0195, PDE5A, HOXC8, ZNF83, ZFP36L2, ZFP14, MPP5, SPP1, ACAP2, MARK1, TOM1L1, TXNDC15, CLVS1, MBTPS2, C2orf69, BRAP, SIPA1L2, ZNF563, TMF1, IPO8, S1PR1, ZNF568, FLT1, BTBD3, ARHGEF3, TCERG1, ZNF468, RLF, ITSN1, KLF6, ZNF136, MLL, CTDSPL, SLC4A10, SLC25A37, DDX3Y, MAGOHB, YLPM1, UBP1, RPS6KB1, YTHDC2, C15orf29, PGAP1, ZNF673, METAP1, SYNPR, PITPNB, AFG3L2, FGD4, PBMUCL1, CDON, LPCAT2, DDX3X, HOXD1, ESM1, ZFP62, CLMN, TMEM165, MPP7, PAPD5, ZFP82, PI4K2B, CLIP1, NEK7, ZNF655, KIAA1239, SLC7A2, ACVR2B, ST8SIA4, ZFP36L1, KRAS, PLDN, RALGAPB, PROX1, GPD2, TBC1D1, TIMP3, BRWD1, BIRC6, HSP90B1, CBX7, CLASP1, ETV6, E2F5, APOO, MED8, PAM, GPBP1, PDCD6IP, HEY2, KIAA0182, DNAJC13, CPNE2, CHMP1B, ABI3BP, SPRY4, FHDC1, ATP2B1, LYRM1, GPD1L, BEND3, NLN, CAPRIN1, MKLN1, NR6A1, PHACTR4, BHLHE40, C6orf35, HMBS, TNFRSF11B, TRAK1
	hsa-miR-51b-R+2
	mml-miR-584-5p_R-1	GBP5, DSG3, ZNF583, MORC3, CCDC152, MCPH1, WWP1, ZNF518A, PPFIA1, MIS12, ACYP2, NEGR1, TTC22, HBS1L, GANAB, POGLUT1, ALPK1, NCOR1, CHORDC1, UHRF1BP1, MAP2, CTXN2, NUFIP2, HDAC1, SETD5, USP6NL, NPHP1, LTBP2, ATP6V1E2, PRRX1, AVPR1A, HSD11B1, SETD1B, MYO5B, ANKRD18A, C3orf23, GC, SEC24D, ZNF765, PDHA1, CYP2J2, AIDA, BTNL3, ZNF585A, MTRF1, PPP2CA, ZNF677, ARL13B, CADPS, LRRIQ3, EIF2AK1, DGKB, FOXN3, NRXN1, CD200, ZNF627, CTDSPL2, ANKLE1, CCDC50, PELI2, FREM1, ANXA1, NAA30, LRRTM3, ANGPTL5, LYPD1 NBN, GTF2A2, SLITRK6, PI15, HBD, H2AFJ, PPM1A, UBTD2, CENPQ, SLC25A40, SIGLEC10, C12orf65, CLSPN, HOOK1, UTP11L, GNG12, VPS41, TWISTNB, CD38, XPO7, UBE4B, AKNAD1, ZNF84, C17orf62, ZNF750, PHF6, C17orf100, ADAMDEC1, C18orf63, THBD, N4BP2L1, SLC35D3, TBRG1, TMX1, PRKCQ, PDIA3, TUSC2, CALB1, SLAMF7, PEX5L, DAND5, ZNF354C, SPOPL, ZNF24, TAZ, C17orf75, LRP11, PTTG1IP
	mml-miR-211	KCNMA1,CDH5, POU3F2, CREB5, ELOVL6, TCF12, RAB22A, IL11, SLC37A3, TMEM237, PHOX2B, FBXO22, AP1S2, PERP, RAB22A, HGSNAT, GSTM3, B3GNT5, TMEM64, FAM126A, TLR6, HAPLN1, SOX14, ZSWIM3, SPOP, ACSM2A, ATP10B, XKR9, EPHA5, BIRC2, MTMR7, THPO, ZCCHC10, ACBD7, C9orf72, USP14, PRAMEF8, POLH, SAMD5, SEMA6A, NTRK2, RASL10A, ACSM2B, AQP11, JRKL, CNOT1, C2orf68, INTS2, PPM1K, BTBD1, LYRM2, EPHB6, FUT10, SOX4, ANGPT1, MYCT1, PRAMEF18, PRAMEF19, TCF12, STYK1, YPEL4, TMEM181, C11orf45, SOS1, TMEM213, ADCY1, RNF170, MAPRE2, ARHGEF33, RHOBTB3, RUNX2, FNDC9, SIX1, MGAT3, IL11, EVC2, ELMO1, GSPT1, ZNF654, VN1R1, PRAMEF12, KIAA0564, DUSP16, CLMP, PTP4A1, MRPS17, ADORA2A, DCUN1D3, SH3PXD2A, KIAA0776, RSPO4, CACNG2, C21orf33, IGFBP5, GTF3C1, CSF2RB, DNAJC13, ZNF629, EPHB2, DUSP19, RAB40B, RAB10, TRIM66, ARHGAP30, WWC3, GPR6, NDRG3, COX5A, POLA1, SLC25A24, C10orf11, C11orf57, TMEM194B, FAM155B, FAM160A2, ACSL4, PIGM, TMEM236, GAL3ST3, UBE2J1, NAPG, SLC43A1, C19orf50, ZC3HAV1, NBR1, SLITRK4, SSRP1, TMEM156, STARD13, TTYH1, SPRYD7, REEP1, MCOLN1, KLLN, MYH15, NOVA1, MAPK9, LOC100507421, CBFA2T3, RGS20, HAS2, RNLS, PDCD6, FRAS1, PLD6, PAM, USP28, DRAP1, PRRX1, GUCA1B, ELAVL2, PTPRD, LRP6, RIMS2, PPIC, FOXC1, EMR3, JPH3, AEBP2, EFNB3, CHP, CAMK1, SLA2, LOC221710, C13orf34, CMBL, SPCS3, SF3B1, SLC4A1AP, DGKG, MMP16, NAA38, ESRRG, ZNF793, TPPP, CCDC144A, RAB13, DHX38, ALPL, DUSP3, PPARGC1A, C1orf43, ACAT1, ERC2, DECR1, PJA1, ZNF423, IL7R, AK4, ALS2, EYS, PLXNA2, C19orf42, NRBF2, C17orf64, NXPH4, MLLT3, PID1, FRS2, FAM168B, EEF1E1, LATS1, CCDC40, ENTHD1, RREB1, SLC12A6, RIOK1, RNF217,
	mml-miR-15b-5p	FGF2, SLC11A2, PLAG1, ZBTB34, MGAT4A, PLSCR4, ANO3, UNC80, TSEN2, TNFSF13B, UBE2Q1, FAM59A, CD80, PISD, CCNE1, TRANK1, SLC13A3, IPO7, CYBASC3, KIAA1432, LOC100130451, FASN, CPEB2, ARL2, PPAPDC2, MTMR3, FCRL2, LAMP3, DCLK1, DNAJB4, PHF19, LY9, GFAP, BCAP29, RUNDC3B, KLHDC8B, MYB, PPPDE2, RPS6KA6, GALNT13, N4BP1, RBM12, RAB9B, PAPPA, GPR63, ERCC6, RASGEF1B, PDK3, USP15, HTR2A, PTPN3, EDA, KIF5A, HAUS3, COL12A1, C2orf42, ZNRF2, UBN2, PAFAH1B2, ACTR2, CBX2, ZFYVE20, PCMT1, FZD10, WEE1, SLC9A8, RS1, ZNF323, MAMSTR, KIF1B, BTBD9, HPSE2, ACVR2B, RAB3B, RNF41, KDSR, SMURF1, UBE4B, STK33, ST8SIA3, ASH1L, YRDC, ZMYM2, GABARAPL1, CDCA4, CD28, CBX4, LSM11, ZC3H13, WNT3A, ODZ2, PHKA1, VPS33B, HELZ, SLC20A2, CNTN3, KIF23, PCGF5, ATXN7L1, EIF4G2, BRWD1, KIF21A, TMC7, ZNHIT6, GNAT1, CCDC19, TNRC6B, LRP6, HTR4, SRPRB, FAM73A, BTAF1, OOEP, SYT10, RSBN1, HSPA1B, PTH, CCDC83, SMAD7, AKT3, USP9X, INSR, FAM91A1, AQP11, DRD1, SIRT4, SNRPB2, PEX13, CDC42SE2, LOC221710, GOLGA1, NELF, CD47, FAM123B, SLC9A6, TMEM100, ATXN7L2, WNK3, MKNK1, MYO5B, KIF5C, CD2AP, C1QL3, RBM6, SRGAP2, C8orf86, SLC12A2, CC2D1B, MAFK, TRPC1, EXT2, ANKRD34C, SLC41A2, PTCD3, WWC1, C10orf46, TMEM55A, ZBTB46, DEPDC5, DZIP1, KCNK10, RSPO3, RAD50, CWC15, ZNF317, IFT74, SHOC2, SYDE2, DMTF1, KIAA1530, UBR3, PRDM4, USP25, NAPG, FGF7, PEX12, C14orf37, GPATCH8, ATXN2, SEL1L3, KIAA0317, ATG14, AXIN2, VEGFA, RBMS1, CHEK1, KCNJ11, TMEM85, NHLRC2, UBE4A, C8orf4, ZNF622, OMG, ATP4B, BTRC, MOBKL3, HSPE1-MOBKL3, GLRX, PAG1, CXorf40B
	mml-miR-500a-3p	TRA2B, RFESD, SLC35A3, PEX2, SNX13, SERBP1, RDH11, SUB1, ABCG5, LEKR1, C12orf77, SATB2, ZBTB41, SIK3, LEPROTL1, GSPT1, CLDN1, PRDM4, PPP2R2A, CBLN4, AHR, PPCS, METTL21A, FGF23, EXOC4, SHISA2, NFE2L2, GATAD2B, DNAJC6, USP28, SH2D1A, LAMA3, CCDC17, NLRP11, IMPAD1, IPO9, TMBIM4, VASH2, UBE3A, ARHGAP20, ZNF274, CCNC, LOC730159, TXNRD1, LRP1B, SMC4, DCLRE1A, PCOLCE2, EFHA2, CROT, TEKT3, FAM116A, C9orf91, TM9SF1, FAM45A, SRSF10, SRSF3, ZFR, EPB41L5, FCHO2, SRGN, TNC, ZNF718, C9orf40, MTMR6, FAM178A, PTPN21, ZNF451, ZNF175, LA2G12A, CLIC4, DACH1, MAPKAPK3, SULF1, LPAR1, ZBTB34, FAM176A, IFRD2, TRABD, IL18BP, TMEM47, CLMN, UBE2L3, IKZF2, GRAMD1C, TRMT2B, HMGCS1, BCL2L15, SKA3, ADI1, ZBTB20
Increased miR expression due to THC/SIV compared to VEH/SIV	mml-miR-7_R+1
	hsa-miR-137
	hsa-miR-488-5p_R+2	AR, CYP2E1
	mml-miR-628-5p	LMLN, FAM105A, ATG4A,, RABGEF1, PTN, PLCE1, GOLT1B, KATNAL2, NR1D2, ANK3, ZNF148, DDX59, STK40, ZSCAN22, EFR3A, RAG1, ASCC3, PRTG, SIP1, GRIP1, DMC1, COG6, FAM168B, TXNDC16, BRD9, AP4E1, C3orf19, CISD1, L2HGDH, STX7, UBXN2B, ZNF323, ZNF828, CD80, SMYD1, PIGH, ATXN3, LOC100507203, NXT2, RNF14, KTN1, EMILIN3, PPP1R3D, A1CF, STK24, KIAA0319, DDO, ANP32E, LAPTM4B, CCDC146, CANT1, PTP4A1, BNIP3L, BRMS1L, NBEA, TAF7, ALS2CR11, FUT8, PSTPIP2, PVRIG, EMR2, PLEKHN1, C20orf108, BIRC6, LARS2, ZNF434, HYDIN, RFX4, EAF1, EFCAB4B, SLAMF7, C6orf168, TCEB1, SCN1A, WDR64, BCL6, NSUN7, INSIG1, ZNF793, KCNK2, ERMAP, CCDC144NL, ATP2A2, DOK2, IGFBP3, MGEA5, C1orf141, ZNF791, CAST, SLC26A4, FUT9, RSPH3, XIRP1, OSMR, ERVV-2, BRP44, FNDC5, SLC5A1, MFAP3, ERVV-1, IPO5, TYROBP, SKA1, PDLIM1, BBS1, RASSF8, HTRA1, KREMEN2, ZSWIM1, SLC46A3, COL19A1, LOXL3, NAT2, YAF2, PTGS2, MTDH, GYPA, HNMT, MUC21, PID1, RNF41, ZFP3, NPEPPS, SLC44A5, DCX, SMARCAD1, ST6GAL1, TCF21, AHCYL2, SELS, MAGEA3, MAGEA6, ELOVL1, GPR88, PRR23B, E2F3, SOCS6, KAZN, AHR, RNF169, EIF5A2, ZNF705D, C5orf44, BBS4, CCR1, ARHGAP36, CXCL14, NFE2L3, MLANA, TGM4, NHEJ1, ESRP1, LYPLA1, CGN, COX15, COL4A1, LSM14A, TMEM33, MRPL49, MCU, SPRED1, EPHA3, ALG6, PLD5, SCN3A, HTATIP2, MS4A15, THAP3, SCN2A, PPFIBP1, MYL6, LAMC3, ZCCHC14, NT5E, SLAIN1, ERI1, SETD8, RDH12, LYN, TSPYL1, FKBP5, ZMAT4, ZPLD1, PRKCE, AGTRAP, THRB, GPATCH4, MAGEB3, KLHL9, EPOR, ARF6, ZNF69, ZCCHC24, AARS, KIAA1804, SGMS1, FLRT3, ABRA, C1orf86, BMS1, ZNF207
	mml-miR-299-3p	CUX1, PAIP2B, TCF4, GCFC1, ABCE1, SP4, PRSS22, ADD1, ANK1, KNDC1, CHST2, LUC7L3, MOGS, VEGFA, ENY2, RAB6A, ARAP3, DNAJA2, TMEM155, UBE2H, POGK, ZNFX1
	hsa-miR-105-5p
	hsa-miR-488-3p	ZNF563, FBN1, C6orf162, FRYL, C7orf41, IGF1, OLFML1, RNGTT, GRIA3, ENAM, PPFIA1, POLR1D, TM6SF2, PRR14L, ZIC5, SLC4A7, GORAB, PCDH18, VPS29, FAM178A, CEP170, NAT8, TMOD2, RAB11FIP1, PSEN1, CDKL4, AKAP13, TACC3, ADAM9, ZNF136, RAB9B, CYorf15B, POMC, C17orf101, CCNG1, AEBP2, H2AFY2, NFXL1, RPS6KA6, BTC, FAM108B1, CGNL1, DAZ1, DAZ3, DAZ2, DAZ4, C4orf3, ARSB, SPINLW1-WFDC6, NETO2, DCUN1D5, STON1, C9orf72, CAV2, IL6ST, CADPS2, C3orf25, NADK, SFTPA1, POU3F4, DSE, EIF3A, UPF3A, TTC9C, KIF18A, FAM101B, DAZL, GTPBP3, KLLN, NRSN2, GPSM2, TIA1, GRAMD3, UBC, PPAP2B, SPDYE3, UBASH3B, MYO1B, POU4F1, MDFIC, PRDM10, SESTD1, TMEM85, ZNF439, DCX, SLC19A3, PHACTR4, ZNF780B, HOOK1, CENPO, BCL7A, SLC35D3, IER3IP1, VAMP4, SEC61G, TAF2, SLCO1C1, KRTAP4-8, ARPP19, PRRC2B, CHRM5, PDC, ARPC5, SLC22A23, RDH12, LOC147670, C5orf42, CREBZF, TACSTD2, BIVM, TRAM1L1, NDFIP2, TRIM58, DDX4, POPDC3, RASGRP3, BTG1, TRMT1L, PAK3, KRTAP1-3, C10orf12, LOC100289187, MYLK3, FAM57A, ATAT1, PCDHB4, TDRD6, RICTOR, FAM13B, SLC7A1, MYO5C, KIAA1377, MED1, SEC63, ERMN, ANKRD13C, SPDYE5, ODZ1, IREB2, SPDYE1, SPDYE6, SETD4, KLHL8, SRD5A3, SERINC1, AIM1, MICAL3, DENND2C, MUC15, BTN3A1, MMP1, LGI1, C1GALT1, PARK2, SERPIND1
	hsa-miR-23a-3p	RING1, CXCL12, HES1, POU4F2, Celf1, ATAT1, IL6R, PPARGC1A, G6PC, FOXO3, FANCG, MYH1, MYH2, MYH4, PTEN, PTPN11, HMGN2, ZNF117, ZNF138, ZNF208, ZNF493, ZNF107, ZNF676, ZNF626, KIAA1467, ZNF257, ZNF680, CARD8, ZNF765, MBOAT7, ZNF721, WBP2, PDE4B, ZIC4, MRC1, AUH, ZNF267, C2orf69, PNRC2, ALG6, CNOT4, MAK16, INTU, DEPDC1, FYB, ZNF254, SYT4, ZNF701, COG3, SCG5, TOP1, RUFY2, GPR155, POU4F2, PKP4, SLC6A14, TMEM68, SEMA6D, C3orf52, ZNF816-ZNF321P, ZNF732, ZNF761, PDE7A, PPP4R4, RAB8B, CDC40, CRISPLD1, LIN54, PCMTD2, RALYL, ZNF287, TMOD2, TMED5, FUT9, ZNF253, RGS18, RPL31, MTHFS, ST20-MTHFS, ZNF91, TMPO, MYCT1, ZNF30, ZNF100, CXCL12, USP51, DOCK3, RAB39B, ZNF708, NAP1L5, ZNF506, TMEM33, CTCF, MYH4, SATB1, C13orf34, TBC1D24, EMR2, PRPH2, TXLNG, CAB39, TNRC6A, SMN1, SMN2, SETD8, NEK6, PRKRIR, SLC38A2, SEC14L1, RAD51AP1, CNTLN, SERINC1, NUP50, RBM25, ATP6V1E1, HNF4G, TRAPPC6B, GLB1L3, PAH, SNRPG, KLF3, CYorf15B, UBL3, LOC100130932, ZNF395, APAF1, DPY19L4, SST, PPARGC1A, USP53, SEC23A, QSER1, FBXO32, EXOC3L4, ACSS3, VCAN, SPG20, SV2B, COL4A4, THUMPD3, PRLR, ZNF420, SEC23IP, C1orf96, ITGAL, CDC23, NACC2, GABRG1, ZNF28, RNF168, EFHA2, ABCC5, SNX5, AMBRA1, TBC1D12, C9orf5, TLK1, SLC12A1, ZNF780B, HEXIM1, CNOT6L, CLEC12B, LPHN2, LYZ, AUTS2, MTF1, SLC38A1, ZNF90, RNF38, ZBTB34, PNMA2, ARHGAP20, TNFAIP3, ALDH1A2, TPST1, HPGD, PIGX, ANKRD33B, ANKHD1, NLGN4X, CHUK, UBE2R2, ZDBF2, FGD4, DDX47, TADA1, CCNH, ZNF114, TRIM14, MAP7, FAS, IGSF8, TJP1, EXOC1, F2R, MT2A, PCDH18, GPRASP1, C13orf27, UTP23, ZDHHC21, MCM4, MAGEA5, MAGEA10-MAGEA5, C15orf32, LRAT, SLMO2, NFX1, FAM120AOS, DCLRE1A, CLDN12, SEC24A, SMPX, FILIP1, B4GALT4, PRDM10, KPNA4
	mml-miR-767-5p