Table 7.
Biological processes enriched by target genes of miRs that were increased or decreased in THC/SIV compared to VEH/SIV striatum
| Category | miRs | Biological process of target genes | No. of genes |
|---|---|---|---|
| Decreased miR expression due to THC/SIV compared to VEH/SIV | mml-miR-338-5p_R-1 mml-let-7a-5p hsa-miR-151b_R+3 hsa-miR-181a-2-3p hsa-miR-151b_R+2 mml-miR-584-5p_R-1 mml-miR-211 mml-miR-15b-5p mml-miR-500a-3p |
Regulation of transcription, DNA-dependent (86), from RNA polymerase II (69) | 155 |
| Response to drug (22), hypoxia (15), estradiol (12), organic compounds (10), testosterone (5), glucocorticoid (4), nutrient levels (4), lipopolysaccharide (3) | 75 | ||
| Signal transduction | 54 | ||
| Apoptotic process | 33 | ||
| Regulation of cell proliferation | 47 | ||
| Receptor signaling, NGF (15), Insulin (12), MAPK (11), TGF (9) | 47 | ||
| Cell cycle | 42 | ||
| Blood coagulation | 25 | ||
| Cell adhesion | 25 | ||
| Protein phosphorylation | 21 | ||
| Ubiquitin-dependent protein catabolic process | 12 | ||
| Anterior/posterior pattern specification | 9 | ||
| Response to wounding | 8 | ||
| Regulation of translation | 8 | ||
| Positive regulation of angiogenesis | 5 | ||
| Astrocyte development | 4 | ||
| Aging | 4 | ||
| Inflammatory response | 4 | ||
| Increased miR expression due to THC/SIV compared to VEH/SIV | mml-miR-7_R+1 hsa-miR-137 hsa-miR-488-5p_R+2 mml-miR-628-5p mml-miR-299-3p hsa-miR-105-5p hsa-miR-488-3p hsa-miR-23a-3p mml-miR-767-5p |
Regulation of transcription, DNA-dependent (57), from RNA polymerase II (59) | 116 |
| Signal transduction | 41 | ||
| Multicellular organismal development | 36 | ||
| Receptor signaling EGF (8), insulin (5) LPS (4), ERK (4), NF-kappa B (4), MAPK (4) | 29 | ||
| Apoptotic process | 27 | ||
| Nervous system development | 26 | ||
| Cell adhesion | 25 | ||
| Protein transport | 24 | ||
| Positive regulation of cell proliferation | 19 | ||
| Interspecies interaction between organisms | 18 | ||
| Negative regulation of cell proliferation | 18 | ||
| Chromatin modification | 14 | ||
| Negative regulation of protein phosphorylation | 7 | ||
| Response to LPS (3), glucocorticoid (3) | 6 | ||
| B cell differentiation | 6 | ||
| Cell morphois | 4 | ||
| Positive regulation of smooth muscle cell migration | 4 | ||
| Protein stabilization | 3 | ||
| Cell growth | 3 |