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. 2016 Mar 1;11(3):e0149684. doi: 10.1371/journal.pone.0149684

Table 1. Interactions appearing in the cross-talk in Fig 2.

Interaction parameters Type of Interaction
k1 Insulin dependent activation of ERK
k2 ERK inhibits pIRS1 by activating mTOR
k3 ERK inhibits pAKT through Gab1-PI3K
k4 pAKT inhibits ERK