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. 2016 Mar 1;11(3):e0149252. doi: 10.1371/journal.pone.0149252

Table 4. Multiple births rates (MBR) and rate ratios of fetal and neonatal mortality by multiplicity in participating countries in 2010.

  Total Fetal mortality ≥ 28 weeks Neonatal mortality
Number of births Singletons Multiples Risk ratio Singletons Multiples Risk ratio
Quartile of multiple birth rates Country Singletons Multiples per 1000 total births per 1000 total births RR (95% CI) per 1000 live births per 1000 live births RR (95% CI)
Lowest MBR <15 ‰  Romania 209 120 3933 3.8 15.0 4.0 (3.0–5.2) 4.5 26.8 6.0 (4.9–7.3)
Latvia 18 764 484 4.0 8.5 2.1 (0.8–5.7) 3.2 14.7 4.6 (2.1–9.9)
Lithuania 30 167 810 3.3 7.6 2.3 (1.0–5.3) 2.3 15.1 6.4 (3.5–11.9)
Poland 403 781 11 234 2.9 6.9 2.4 (1.9–3.0) 3.2 15.3 4.8 (4.1–5.7)
Iceland 4 765 138 1.9 0.0 1.9 (0.1–33.0) 0.6 22.2 35.6 (7.3–174.9)
Sweden 111 721 3286 2.7 5.8 2.3 (1.4–3.6) 1.3 9.6 7.2 (4.9–10.5)
Slovakia 54 204 1621 2.9 8.9 3.0 (1.8–5.2) 1.4 16.2 11.5 (7.4–17.9)
Pooled RR 2.8 (2.2–3.5) 6.7 (5.1–8.8)
MBR 15–16 ‰ Estonia 15 412 472 2.7 2.2 0.8 (0.1–5.8) 1.8 4.4 2.4 (0.6–10.0)
Portugal 98 690 3100 2.3 5.6 2.5 (1.5–4.0) 1.4 9.4 6.7 (4.5–10.0)
UK: Northern Ireland 24 902 790 3.3 8.0 2.3 (1.0–5.4) 3.1 25.6 8.7 (5.3–14.2)
Finland 59 484 1887 1.9 5.4 2.9 (1.5–5.6) 1.2 11.7 9.9 (6.2–16.0)
UK: England and Wales 699 494 22 431 3.6 8.3 2.3 (2.0–2.6) 2.2 12.4 5.6 (4.9–6.3)
Italy 529 226 17 293 2.2 6.8 3.0 (2.5–3.7) 1.4 11.4 8.2 (7.0–9.6)
UK: Scotland 57 860 1813 3.5 7.4 2.2 (1.2–3.8) 2.1 14.6 6.8 (4.5–10.4)
Norway 60 831 2081 2.1 7.6 3.6 (2.1–6.2) 1.7 10.2 6.2 (3.9–9.9)
BE: Wallonia 37 133 1297 2.8 16.0 5.7 (3.6–9.2) 1.5 19.0 12.5 (7.8–20.1)
Pooled RR 2.6 (2.2–3.0) 7.0 (5.7–8.5)
MBR 17–18 ‰ Ireland 73 041 2554 3.7 3.6 1.0 (0.5–1.9) 1.8 10.3 5.6 (3.7–8.5)
Austria 76 226 2763 2.4 4.5 1.9 (1.0–3.4) 1.7 15.6 9.4 (6.6–13.2)
France 14 455 443 4.1 11.4 2.8 (1.1–6.9) NA NA -
Netherlands 172 707 6131 2.6 10.3 3.9 (3.0–5.1) 2.9 14.6 5.0 (4.0–6.2)
Luxembourg 6 321 239 2.9 4.4 1.5 (0.2–11.5) 0.6 25.6 40.3 (11.4–141.8)
Switzerland 77 314 2962 1.9 8.8 4.7 (3.1–7.1) 1.9 18.5 9.5 (7.0–12.9)
Slovenia 21 589 827 3.2 6.3 2.0 (0.8–4.9) 1.3 14.7 11.3 (5.8–22.1)
Germany 613 796 23 868 2.2 4.4 2.0 (1.7–2.5) NA NA -
Pooled RR 2.4 (1.7–3.5) 8.4 (5.8–12.3)
Highest MBR ≥19 ‰  BE: Flanders 67 330 2646 2.6 8.6 3.3 (2.1–5.1) 1.8 13.8 7.5 (5.2–10.9)
Malta 3 872 164 3.1 12.5 4.0 (0.9–17.8) 4.4 6.2 1.4 (0.2–10.5)
Spain 383 262 16 891 2.5 5.9 2.3 (1.9–2.9) NA NA -
Denmark 60 899 2614 2.3 2.0 0.8 (0.3–2.1) 1.6 8.4 5.1 (3.2–8.1)
Czech Republic 112 116 4804 1.4 1.7 1.2 (0.6–2.4) 1.4 8.6 6.3 (4.5–8.9)
BE: Brussels 23 932 1149 3.9 7.2 1.8 (0.9–3.8) 2.6 5.3 2.0 (0.9–4.7)
Cyprus 8 120 461 NA NA - NA NA -
Pooled RR 2.4 (1.5–3.6) 5.9 (3.8–9.0)
All countries Weighted average 4 128 350 141 156 2.9 7.0 2.1 13.9
Median 30 countries 2.8 7.0 27 countries 1.8 14.6
Pooled RR 2.4 (1.5–3.6) 7.0 (6.1–8.0)

NOTE: Gestational age = best obstetric estimate in completed weeks. Data from France are from a nationally representative survey. Data from Cyprus are from 2007.