Table 2. Association between biomarkers of DNA damage and repair (pWee1 and γ-H2AX) and pathological complete response in cervical cancer patients treated with neoadjuvant chemotherapy (N = 52).
| Pathological complete response | |||
|---|---|---|---|
| No | Yes | Fisher's Exact Test | |
| Biomarker | N (%) | N (%) | P-value |
| pWee1neg | 13 (52.0) | 12 (48.0) | 0.016 |
| pWee1pos | 23 (85.2) | 4 (14.8) | |
| pWee1allred low | 13 (52.0) | 12 (48.0) | 0.016 |
| pWee1allred high | 23 (85.2) | 4 (14.8) | |
| pWee1multi low | 14 (53.8) | 12 (46.2) | 0.034 |
| pWee1multi high | 22 (84.6) | 4 (15.4) | |
| γ-H2AXcat low | 15 (55.6) | 12 (44.4) | 0.037 |
| γ-H2AXcat high | 21 (84.0) | 4 (16.0) | |
pWee1, phosphorylated Wee1-like protein kinase; γ-H2AX, phosphorylated H2A Histone Family Member X