Fig 7. M. abscessus subsp. massiliense bacillary load reduction in IFN-γKO-infected mice after treatment with Polydim-I peptide.

IFN-γKO mice were infected intravenously with 10⁶ CFU of M. abscessus subsp. massiliense. Eighteen days after infection, the mice were treated with Polydim-I peptide at three different dosages (2, 1 or 0.5 mg/kg/mLW) or with clarithromycin (CLR 200 mg/kg/mLW). As a control group, infected mice were treated with PBS. Percentages of bacterial load reduction in the lungs (A), spleen (B) and liver (C) from each treatment group were determined relative to the control PBS group (* p<0.05).