Table 4. Diagnostic criteria of the ROC curve for tested parameters and CA 15-3.
| Parameters tested | ROC criteria in breast cancer total group | |||
|---|---|---|---|---|
| AUC | Sensitivity | 95% CI | P | |
| M-CSF | 0.7955 | 0.0381 | 0.721-0.870 | < 0.001 |
| MMP-9 | 0.6827 | 0.0511 | 0.582-0.783 | < 0.001 |
| TIMP-1 | 0.6250 | 0.0574 | 0.513-0.738 | 0.0294 |
| CA 15-3 | 0.8548 | 0.0346 | 0.787-0.923 | < 0.001 |
| M-CSF + CA 15-3 | 0.8840 | 0.0287 | 0.828-0.940 | < 0.001 |
| MMP-9 + CA 15-3 | 0.8851 | 0.0289 | 0.829-0.942 | < 0.001 |
| TIMP-1 + CA 15-3 | 0.8547 | 0.0346 | 0.787-0.922 | < 0.001 |
| M-CSF + MMP-9 + TIMP-1 + CA 15-3 | 0.9125 | 0.0241 | 0.865-0.960 | < 0.001 |
P-statistically significantly larger AUCs compared with AUC=0.5.
Abbreviations: AUC, area under the ROC curve; CI, confidence interval; MMP-9, matrix metalloproteinase-9; TIMP-1, tissue inhibitor of metalloproteinases-1; M-CSF, macrophage colony-stimulating factor.