Table 5.
Predicted restrictions of TB epitopes in Macaques.*
| Antigen | Sequence | Allele | A+R+ | A−R+ | A+R− | A−R− | RF | P-value |
|---|---|---|---|---|---|---|---|---|
| Rv0288 | AMEDLVRAYHAMSST | DPA1*02:g2 | 3 | 0 | 3 | 9 | 2.5 | 0.044 |
| DPB1*07:01 | 3 | 0 | 3 | 9 | 2.5 | 0.044 | ||
| Rv3620c | ATSLDTMTQMNQAFR | DQB1*18:g2 | 2 | 1 | 0 | 12 | 5.0 | 0.029 |
| DRB*W1:g1 | 2 | 1 | 0 | 12 | 5.0 | 0.029 | ||
| DRB*W6:02 | 2 | 1 | 0 | 12 | 5.0 | 0.029 | ||
| DRB*W6:g2 | 2 | 1 | 0 | 12 | 5.0 | 0.029 | ||
| DRB1*03:g2 | 2 | 1 | 0 | 12 | 5.0 | 0.029 | ||
| Rv3874 | EISTNIRQAGVQYSR | DQB1*18:g1 | 5 | 0 | 4 | 6 | 1.7 | 0.044 |
| Rv3620c | MTDPHAMRDMAGRFE | DQB1*18:g2 | 2 | 1 | 0 | 12 | 5.0 | 0.029 |
| DRB*W1:g1 | 2 | 1 | 0 | 12 | 5.0 | 0.029 | ||
| DRB*W6:02 | 2 | 1 | 0 | 12 | 5.0 | 0.029 | ||
| DRB*W6:g2 | 2 | 1 | 0 | 12 | 5.0 | 0.029 | ||
| DRB1*03:g2 | 2 | 1 | 0 | 12 | 5.0 | 0.029 |
*
A+: genotyped HLA allele positive; A−: genotyped HLA allele negative; R+: epitope response positive; R−: epitope response negative. P value is calculated from Fisher exact test from A+R+, A−R+. A+R−, and A−R−.