Table 1.
Summary of proBDNF receptor binding kinetics.
| n | (ka ± s.e.m.) × 106 (M−1 s−1) | (kd ± s.e.m.) × 10−3 (s−1) | (KD ± s.e.m.) × 10−9 (M) | P of KD Val66 vs Met66 | |
|---|---|---|---|---|---|
| TrkBIg2 | |||||
| Val66 | 4 | 1.61 ± 0.31 | 3.67 ± 0.52 | 2.32 ± 0.09 | 0.780 |
| Met66 | 3 | 1.99 ± 0.47 | 3.92 ± 0.67 | 2.03 ± 0.14 | |
| BDNF | 7 | 4.57 ± 0.76 | 2.32 ± 0.43 | 0.58 ± 0.13 | |
| P75NTR ECD | |||||
| Val66 | 5 | 1.88 ± 0.48 | 3.94 ± 0.87 | 2.42 ± 0.18 | 0.502 |
| Met66 | 5 | 1.55 ± 0.43 | 3.25 ± 0.48 | 2.31 ± 0.22 | |
| BDNF | 4 | 4.44 ± 0.68 | 2.51 ± 0.12 | 0.62 ± 0.12 | |
| Sortilin LD | |||||
| Val66 | 5 | 2.48 ± 0.63 | 7.46 ± 2.27 | 2.90 ± 0.37 | 0.312 |
| Met66 | 6 | 1.56 ± 0.37 | 5.04 ± 0.87 | 3.83 ± 0.84 | |
| BDNF | 7 | 3.80 ± 1.37 | 21.7 ± 9.01 | 6.44 ± 1.61 | |
| SorCS2 LD | |||||
| Val66 | 3 | 1.79 ± 0.23 | 4.00 ± 0.84 | 2.23 ± 0.21 | 0.614 |
| Met66 | 3 | 2.135 ± 0.45 | 4.53 ± 0.36 | 2.23 ± 0.30 | |
| BDNF | 3 | Low affinity | Low affinity | Low affinity | |