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. 2016 Jan 20;6:700–705. doi: 10.1016/j.dib.2016.01.017

Fig. 2.

Fig. 2.

Repeated intravenous administration of RVG-9r-targeted SNALPs does not elicit local microglial activation. 8 weeks after starting the treatment, mice were sacrificed and Iba-1 staining was evaluated by fluorescence immunohistochemistry. (A–C) Fluorescence microscopy images of microglia stained with Iba-1 antibody, with a 5× objective. (D) Quantification of the Iba-1 immunoreactivity. Values are presented as mean±SEM of n=5/6. One-way ANOVA analysis of variance combined with Bonferroni’s post-test was used to compare animals injected with HBS versus siMutAtax3 and siCTR (n.s. p>0.05). (E–G) Fluorescence microscopy images of microglia stained with Iba-1 antibody, with a 20× objective.