Figure 3.

A network of diverse regulatory inputs controls RovA transcriptional output in Yersinia. Available RovA is strictly controlled by cascade regulation at both the transcriptional and post-transcriptional levels in response to multiple environmental cues. The strongest influence on RovA production is through two opposing pathways. The first is an auto amplification loop, which in turn is responsive to thermo-regulated proteolysis of RovA by ClpXP and Lon proteases. The second is via RovM that is principally mediated by the prominent Csr and Crp pathways responsive to carbon and glucose availability. Other regulatory pathways are known, but the extent to which they alter RovM or RovA levels is less clear. In the diagram, induction of RovA expression is indicated by an arrow, while repression is indicated by a blunted line. For simplicity, information concerning whether the pathway is direct or indirect has been omitted on the basis that this is not always defined.