Figure 5. Zfp423 overexpression differentially impacts survival.

(a) AstroEGFR* cell lines were infected with retroviral vectors expressing Zfp423 and Zfp423 overexpression levels were then measured by qRT–PCR. Data are represented as dCt (log₂ scale) relative to Tbp; error bars represent the s.d. of technical replicates. (b) Kaplan–Meyer analysis of survival in mice injected with the three batches of AstroEGFR* (light grey) and AstroEGFR* overexpressing Zfp423 (purple). Numbers of animals for each category are indicated in brackets in the caption. Difference in progression-free survival between animals injected with AstroEGFR*2 and AstroEGFR*2 Zfp423 is statistically significant.