Table 3.
Significant 9p21 SNP associations with CAC-c in EUA and HIS. There were no significant SNPs in AFA and CHN. SNPs were selected 100 kb upstream/downstream from SNPs rs1333049, rs4977574, and rs16905644. A total of 3282 SNPs were identified (598, 631, 1256 and 797 SNPs in EUA, CHN, AFA and HIS, respectively). The Bonferroni corrected p-value was determined by dividing 0.05 by the number of SNPs used in which ethnicity.
| SNP | Position | Beta | P-value | MAF |
|---|---|---|---|---|
| EUA | ||||
| rs3218020 | 21,997,872 | 0.342 | 2.09E−07 | 0.369 |
| rs3217992 | 22,003,223 | 0.310 | 1.58E−06 | 0.406 |
| rs1063192 | 22,003,367 | 0.283 | 8.43E−06 | 0.584 |
| rs2069418 | 22,009,698 | 0.271 | 1.80E−05 | 0.568 |
| rs2069416 | 22,010,004 | 0.282 | 2.50E−05 | 0.362 |
| rs10,811,641 | 22,014,137 | 0.324 | 5.54E−07 | 0.385 |
| rs523096 | 22,019,129 | −0.263 | 2.75E−05 | 0.423 |
| rs518394 | 22,019,673 | −0.258 | 3.90E−05 | 0.422 |
| rs568,447 | 22,021,615 | −0.273 | 2.06E−05 | 0.546 |
| rs10738604 | 22,025,493 | 0.324 | 5.75E−07 | 0.381 |
| rs613312 | 22,026,594 | −0.269 | 1.94E−05 | 0.398 |
| rs543830 | 22,026,639 | −0.269 | 1.94E−05 | 0.398 |
| rs1591136 | 22,026,834 | 0.247 | 7.82E−05 | 0.491 |
| rs599452 | 22,027,402 | −0.269 | 1.94E−05 | 0.398 |
| rs62560774 | 22,028,406 | −0.267 | 7.00E−05 | 0.301 |
| rs679038 | 22,029,080 | −0.269 | 1.92E−05 | 0.398 |
| rs10965215 | 22029445 | 0.245 | 8.36E−05 | 0.493 |
| rs564398 | 22029547 | −0.273 | 1.46E−05 | 0.399 |
| rs7865618 | 22,031,005 | 0.292 | 3.39E−06 | 0.594 |
| rs634537 | 22,032,152 | −0.275 | 1.29E−05 | 0.399 |
| rs2157719 | 22,033,366 | 0.292 | 3.45E−06 | 0.595 |
| rs1008878 | 22,036,112 | 0.293 | 3.31E−06 | 0.594 |
| rs1556515 | 22,036,367 | 0.293 | 3.30E−06 | 0.594 |
| rs1333037 | 22,040,765 | 0.290 | 4.56E−06 | 0.596 |
| rs1412830 | 22,043,612 | −0.268 | 4.38E−05 | 0.355 |
| rs1412829 | 22,043,926 | −0.278 | 1.10E−05 | 0.400 |
| rs1360589 | 22,045,317 | 0.298 | 2.61E−06 | 0.596 |
| rs7028268 | 22,048,414 | 0.333 | 2.21E−07 | 0.407 |
| rs10757265 | 22,048,859 | 0.249 | 7.69E−05 | 0.491 |
| rs944800 | 22,050,898 | 0.298 | 9.66E−06 | 0.690 |
| rs944801 | 22,051,670 | 0.299 | 2.34E−06 | 0.596 |
| rs6475604 | 22,052,734 | 0.300 | 2.26E−06 | 0.596 |
| rs7030641 | 22,054,040 | 0.299 | 2.41E−06 | 0.595 |
| rs7039467 | 22,056,213 | 0.315 | 3.49E−06 | 0.526 |
| rs7853090 | 22,056,295 | 0.324 | 1.39E−06 | 0.555 |
| rs7866783 | 22,056,359 | 0.293 | 3.63E−06 | 0.588 |
| rs10757268 | 22,059,905 | 0.275 | 6.16E−05 | 0.709 |
| rs2095144 | 22,060,136 | 0.275 | 6.20E−05 | 0.709 |
| rs2383205 | 22,060,935 | 0.269 | 2.81E−05 | 0.616 |
| rs2184061 | 22,061,562 | 0.269 | 2.83E−05 | 0.613 |
| rs1537378 | 22,061,614 | 0.268 | 2.96E−05 | 0.616 |
| rs8181050 | 22,064,391 | 0.265 | 3.42E−05 | 0.617 |
| rs10811647 | 22,065,002 | 0.317 | 7.24E−07 | 0.450 |
| rs1333039 | 22,065,657 | 0.266 | 3.09E−05 | 0.614 |
| rs4977755 | 22,066,363 | 0.270 | 2.58E−05 | 0.613 |
| rs10965223 | 22,067,004 | 0.267 | 3.25E−05 | 0.612 |
| rs10965224 | 22,067,276 | 0.264 | 3.52E−05 | 0.613 |
| rs10811648 | 22,067,542 | 0.265 | 3.39E−05 | 0.614 |
| rs10811649 | 22,067,554 | 0.265 | 3.26E−05 | 0.614 |
| rs10811650 | 22,067,593 | 0.329 | 2.26E−07 | 0.447 |
| rs10811651 | 22,067,830 | 0.264 | 3.55E−05 | 0.614 |
| rs4977756 | 22,068,652 | 0.265 | 3.30E−05 | 0.615 |
| rs4451405 | 22,071,750 | 0.280 | 1.90E−05 | 0.583 |
| rs4645630 | 22,071,751 | 0.278 | 2.21E−05 | 0.580 |
| rs10757269 | 22,072,264 | 0.381 | 1.33E−09 | 0.517 |
| rs9632884 | 22,072,301 | 0.366 | 1.05E−08 | 0.524 |
| rs9632885 | 22,072,638 | 0.376 | 2.00E−09 | 0.509 |
| rs10757270 | 22,072,719 | 0.320 | 3.68E−07 | 0.448 |
| rs1831733 | 22,076,071 | 0.388 | 1.98E−09 | 0.492 |
| rs10757271 | 22,076,795 | 0.410 | 8.83E−11 | 0.519 |
| rs10811652 | 22,077,085 | 0.412 | 6.79E−11 | 0.517 |
| rs1412832 | 22,077,543 | 0.292 | 2.11E−05 | 0.701 |
| rs10116277 | 22,081,397 | 0.406 | 9.13E−11 | 0.509 |
| rs6475606 | 22,081,850 | 0.406 | 7.71E−11 | 0.510 |
| rs1547705 | 22,082,375 | 0.576 | 1.31E−05 | 0.118 |
| rs1333040 | 22,083,404 | 0.388 | 1.12E−09 | 0.600 |
| rs1537370 | 22,084,310 | 0.408 | 8.66E−11 | 0.507 |
| rs1,970,112 | 22,085,598 | 0.395 | 3.33E−10 | 0.500 |
| rs7,857,345 | 22,087,473 | 0.311 | 1.39E−05 | 0.721 |
| rs10,738,606 | 22,088,090 | 0.363 | 4.56E−09 | 0.511 |
| rs10,738,607 | 22,088,094 | 0.363 | 4.56E−09 | 0.511 |
| rs10,757,272 | 22,088,260 | 0.360 | 6.01E−09 | 0.510 |
| rs10,757,273 | 22,090,301 | 0.402 | 1.89E−09 | 0.482 |
| rs9,644,859 | 22,090,521 | 0.453 | 3.66E−11 | 0.455 |
| rs9644860 | 22,090,603 | 0.426 | 1.06E−10 | 0.485 |
| rs9644862 | 22,090,936 | 0.436 | 1.83E−10 | 0.449 |
| rs10811653 | 22,091,069 | 0.407 | 9.51E−10 | 0.479 |
| rs7866503 | 22,091,924 | 0.397 | 4.90E−09 | 0.466 |
| rs2210538 | 22,092,257 | 0.400 | 7.12E−10 | 0.494 |
| rs141014318 | 22,092,924 | 0.361 | 8.43E−09 | 0.499 |
| rs4977757 | 22,094,330 | 0.386 | 1.17E−09 | 0.501 |
| rs10738608 | 22,094,796 | 0.403 | 1.54E−10 | 0.520 |
| rs10757274 | 22,096,055 | 0.368 | 3.18E−09 | 0.512 |
| rs4977574 | 22,098,574 | 0.366 | 3.84E−09 | 0.511 |
| rs2891168 | 22,098,619 | 0.358 | 7.58E−09 | 0.511 |
| rs1556516 | 22,100,176 | 0.392 | 3.34E−10 | 0.528 |
| rs7859727 | 22,102,165 | 0.368 | 3.15E−09 | 0.515 |
| rs1537372 | 22,103,183 | 0.329 | 2.93E−07 | 0.451 |
| rs1537373 | 22,103,341 | 0.391 | 3.68E−10 | 0.528 |
| rs1333042 | 22,103,813 | 0.387 | 5.38E−10 | 0.531 |
| rs7859362 | 22,105,927 | 0.386 | 8.58E−10 | 0.535 |
| rs10757275 | 22,106,225 | 0.367 | 5.35E−09 | 0.519 |
| rs6475609 | 22,106,271 | 0.386 | 8.57E−10 | 0.535 |
| rs1333043 | 22,106,731 | 0.386 | 8.56E−10 | 0.535 |
| rs1412834 | 22,110,131 | 0.380 | 1.60E−09 | 0.536 |
| rs7341786 | 22,112,241 | 0.380 | 1.75E−09 | 0.538 |
| rs7341791 | 22,112,427 | 0.381 | 1.63E−09 | 0.538 |
| rs10511701 | 22,112,599 | 0.355 | 1.68E−08 | 0.527 |
| rs10733376 | 22,114,469 | 0.381 | 1.75E−09 | 0.532 |
| rs10738609 | 22,114,495 | 0.358 | 1.13E−08 | 0.520 |
| rs2383206 | 22,115,026 | 0.387 | 8.47E−10 | 0.531 |
| rs944797 | 22,115,286 | 0.387 | 8.28E−10 | 0.531 |
| rs1004638 | 22,115,589 | 0.381 | 1.43E−09 | 0.536 |
| rs2383207 | 22,115,959 | 0.382 | 1.42E−09 | 0.536 |
| rs1537374 | 22,116,046 | 0.381 | 1.43E−09 | 0.536 |
| rs1537375 | 22,116,071 | 0.354 | 1.70E−08 | 0.525 |
| rs1537376 | 22,116,220 | 0.387 | 8.69E−10 | 0.531 |
| rs1333045 | 22,119,195 | 0.349 | 3.93E−08 | 0.530 |
| rs10217586 | 22,121,349 | 0.327 | 2.56E−07 | 0.549 |
| rs10738610 | 22,123,766 | 0.355 | 1.37E−08 | 0.517 |
| rs1333046 | 22,124,123 | 0.357 | 1.08E−08 | 0.517 |
| rs7857118 | 22,124,140 | 0.380 | 1.53E−09 | 0.533 |
| rs10757277 | 22,124,450 | 0.378 | 1.72E−09 | 0.498 |
| rs10811656 | 22,124,472 | 0.394 | 7.58E−10 | 0.491 |
| rs10757278 | 22,124,477 | 0.378 | 1.72E−09 | 0.498 |
| rs1333047 | 22,124,504 | 0.405 | 1.57E−10 | 0.515 |
| rs10757279 | 22,124,630 | 0.379 | 1.50E−09 | 0.498 |
| rs4977575 | 22,124,744 | 0.405 | 1.40E−10 | 0.514 |
| rs1333048 | 22,125,347 | 0.350 | 1.65E−08 | 0.519 |
| rs1333049 | 22,125,503 | 0.371 | 2.00E−09 | 0.493 |
| rs1333050 | 22,125,913 | 0.332 | 3.83E−05 | 0.670 |
| HIS | ||||
| rs10757270 | 22,072,719 | 0.278 | 5.28E−05 | 0.422 |
| rs1970112 | 22,085,598 | 0.288 | 3.24E−05 | 0.473 |
| rs9644860 | 22,090,603 | 0.297 | 5.52E−05 | 0.442 |
| rs9644862 | 22,090,936 | 0.331 | 7.94E−06 | 0.482 |
| rs10811653 | 22,091,069 | 0.303 | 4.04E−05 | 0.434 |
| rs141014318 | 22,092,924 | 0.289 | 5.09E−05 | 0.399 |
| rs10738608 | 22,094,796 | 0.289 | 4.98E−05 | 0.542 |
| rs4977574 | 22,098,574 | 0.283 | 5.24E−05 | 0.412 |
| rs2891168 | 22,098,619 | 0.280 | 5.81E−05 | 0.416 |