Table 1. Features of index SNPs showing strongest genome-wide significant association (P value <5 × 10−8) to the scalp and facial hair features examined in the CANDELA sample.
| Trait | Region | SNP | Closest gene | P value | Alleles ancestral>derived |
|---|---|---|---|---|---|
| Hair shape | 1q21 | rs11803731 | TCHH | 3 × 10−12 | A>T |
| Hair shape | 2q12 | rs3827760 | EDAR | 3 × 10−119 | A>G |
| Hair shape | 10p14 | rs17143387 | GATA3 | 4 × 10−8 | T>G |
| Hair shape | 16p11 | rs11150606 | PRSS53 | 7 × 10−9 | T>C |
| Beard thickness | 2q12 | rs365060 | EDAR | 1 × 10−15 | G>C |
| Beard thickness | 4q12 | rs4864809 | LNX1 | 1 × 10−8 | A>G |
| Beard thickness | 6q21 | rs6901317 | PREP | 4 × 10−8 | G>T |
| Beard thickness | 7q31 | rs117717824 | FOXP2 | 1 × 10−8 | G>T |
| Eyebrow thickness | 3q22 | rs112458845 | FOXL2 | 4 × 10−10 | G>A |
| Monobrow | 2q36 | rs2218065 | PAX3 | 5 × 10−8 | A>G |
| Hair greying | 6p25 | rs12203592 | IRF4 | 3 × 10−13 | C>T |
| Hair colour | 5p13 | rs183671 | SLC45A2 | 2 × 10−59 | T>G |
| Hair colour | 6p25 | rs12203592 | IRF4 | 1 × 10−13 | C>T |
| Hair colour | 11q14 | rs598952 | TYR | 2 × 10−8 | T>A |
| Hair colour | 15q13 | rs12913832 | HERC2/OCA2 | 5 × 10−104 | A>G |
| Hair colour | 15q21 | rs1426654 | SLC24A5 | 1 × 10−18 | G>A |
| Balding | 10q22 | rs2814331 | GRID1 | 4 × 10−9 | C>T |
| Balding | Xq12 | rs4258142 | AR/EDA2R | 2 × 10−8 | C>T |
SNP, single-nucleotide polymorphism.
Regions with intragenic index SNPs are shown in bold (the gene name is underlined if this index SNP is coding). SNPs in regions reaching only genome-wide suggestive association, P value <10−5, are listed in Supplementary Table 6.