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. 2016 Mar 1;7:10824. doi: 10.1038/ncomms10824

Figure 2. Blocking VEGFR3 activities inhibits corneal lymphangiogenesis in Mmp14−/− mice.

Figure 2

Real-time qPCR analyses of mRNA for Vegf-c (a), Vegf-a (b), Vegf-d (c), Tnf-α (d), Il-1β (e), Mcp-1 (f) and Mip-2 (g) in WT and Mmp14−/− corneas at different ages (P3, P8 and P15) (*P<0.05,**P<0.01, n=5, two-tailed t-test). (h) Corneas from P15 WT and Mmp14−/− mice with or without treatment of neutralizing antibodies against VEGFR-3 (α-VEGFR-3) were immunostained with LYVE-1 (green). Scale bars, 200 μm. (i) Quantification of vascularization area shown in h (*P<0.05; **P<0.01, n=5, two-tailed t-test). Data represent the mean±s.e.m.