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. 2016 Feb 16;2016:2732705. doi: 10.1155/2016/2732705

Figure 2.

Figure 2

The reciprocally regulatory feedback loop between lncRNAs and EMT-TFs that are involved in EMT. lncRNAs form regulatory networks with EMT-TFs and EMT-associated signaling pathways that individually or cooperatively modulate EMT. The EMT-suppressive lncRNAs, H19 and MEG3, can downregulate TGF-β signaling. H19, lncRNA-ATB, and ZEB-AS1 promote EMT-TFs through direct or indirect regulation. In addition, H19 is reported to possess a controversial ability to downregulate Twist though its intergenic miRNA, miR-675. TGF-β and IL-6/STAT3 signaling pathways also promote activity of the lncRNAs, Hotair, lncTCF7, and MALAT1, and thus crosstalk with Notch signaling and Wnt signaling, to modulate EMT process. Dysregulation of these miRNAs and lncRNAs may lead to tumor progression.