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. 2016 Feb 16;2016:2732705. doi: 10.1155/2016/2732705

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Copyright © 2016 Ching-Wen Lin et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

The molecular network composed of miRNAs/lncRNAs and EMT-TFs. miRNAs and lncRNAs form regulatory networks with EMT-TFs and EMT-associated signaling pathways that individually or cooperatively modulate EMT. EMT-suppressing miRNAs reciprocally suppress EMT-TFs and consequently downregulate the expression of epithelial markers. This negative feedback loop can be broken by TGF-β or IL-6/STAT3 signaling, p53, and lncRNAs (e.g., H19, lncRNA-ATB, and ZEB-AS1). Dysregulation of these miRNAs and lncRNAs may lead to tumor progression.