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. 2016 Feb 17;2016:4041827. doi: 10.1155/2016/4041827

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Copyright © 2016 Ryuta Saito et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Schematic diagram of the mathematical model of adrenal steroidogenesis in NCI-H295R cells. Overview of the mathematical model of adrenal steroidogenesis in NCI-H295R cells, including cholesterol transport and intracellular localization, oxysterol synthesis, the C₂₁-steroid hormone biosynthesis pathway, passive diffusional transport of steroid hormones, and cell proliferation. CHOL: total cholesterol in medium culture, CHOS: stored cholesterol esters in the endoplasmic reticulum, CHOC: intracellular free cholesterol, CHOM: mitochondrial free cholesterol, CHON: mitochondrial free cholesterol close to CYP11A1 enzymes, CHOR: mitochondrial free cholesterol remote from CYP11A1 enzymes, PREG: pregnenolone, HPREG: 17α-hydroxypregnenolone, DHEA: dehydroepiandrosterone, PROG: progesterone, HPROG: 17α-hydroxyprogesterone, DIONE: androstenedione, DCORTICO: 11-deoxycorticosterone, DCORT: 11-deoxycortisol, CORTICO: corticosterone, CORT: cortisol, ALDO: aldosterone, TESTO: testosterone, E1: estrone, E2: 17β-estradiol, OXY: oxysterol, CEH: cholesterol ester hydrolase, StAR: steroidogenic acute regulatory protein, CYP11A1: P450 side chain cleavage enzyme, CYP17H: 17α-hydroxylase of CYP17, CYP17L: C_17–20 lyase of CYP17, HSD3B2: 3β-hydroxysteroid dehydrogenase, CYP21A2: 21-hydroxylase, CYP11B1: 11β-hydroxylase, CYP11B2: 18-hydroxylase, HSD17B3: 17β-hydroxysteroid dehydrogenase, and CYP19A1: aromatase.