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. 2016 Feb 17;2016:7291438. doi: 10.1155/2016/7291438

Figure 13.

Figure 13

Modulation of motor-sensory function by 5-HT agonists. (a) Effect of various 5-HT agonists on the number of EPSPs in third-instar larvae. The control group was obtained by changing saline with fresh saline to observe the effect of the saline switching process on EPSPs frequency. The results show that 5-HT significantly increased the number of EPSPs; however, 5-methoxytryptamine (5-MeOHT), 5-carboxamidotryptamine maleate salt (5-CAT), 1-(3-chlorophenyl)piperazine hydrochloride (m-CPP), and LP-44 (5-HT7 agonist) did not produce significant changes. (b) 5-HT2 agonists, BW723C86 (100 nM and 10 μM) (5-HT2B receptor agonist) and R(−)-DOI HCl (1 μM) (5-HT2 receptor agonist), significantly increased the motor-sensory circuit activity. Paired t-test was used to compare the number of EPSPs in saline with saline that contained an agonist. Data represented as mean ± SEM. P < 0.05 is significant.