Figure 14.

Effect in sensitivity to 5-HT modulation in line with disrupted aspects within the 5-HTergic system. 5-HT application on tryptophan hydroxylase (Trh) mutant third-instar larvae markedly increased sensory-motor circuit physiology. 5-HT at 10 μM exposure in CS third-instar larvae seems to desensitize 5-HT receptors since it does not markedly modulate neural circuitry in comparison to 5-HT 100 nM. 5-HT2A receptor mutation significantly reduced the modulatory action of 5-HT. However, mutation in 5-HT7 receptor noticeably responds to 5-HT at 1 μM. Paired t-test was used to compare the number of EPSPs in saline with saline that contained 5-HT. Data represented as mean ± SEM. P < 0.05 is significant.