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Reciprocal regulation of Pegs and Megs in imprinted gene clusters. An insulator model is shown. In this example, paternal allele of DMR is fully methylated while maternal allele is none methylated (paternally imprinted region) like IGF2-H19 region. In the case of IGF2-H19 region, there are several cell-lineage-specific enhancers downstream of H19 but one of them is shown.
