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Emergence of DMRs in imprinted regions in mammals. Paternally and maternally methylated DMRs are shown in blue and red, respectively. The locations of the mouse chromosomes are shown. Only PEG10 and H19-IGF2 DMRs are common to the eutherians and marsupials. *The imprinted regulation of these two regions started in the eutherians associated with chromosome rearrangements near the DMRs. Modified from Fig. 6 in ref. 18.
