Table 3.

Predictors of overall survival from HPI, PMH, and neurological exam on univariate analysis.

Patient characteristic	OR (95% CI)	p-Value
History of present illness
Seizures	1.57 (0.82–3.0)	0.170
Age	1.03 (1.01–1.04)	0.001
Primary diagnosisa	–	<0.001
Breast carcinoma	0.62 (0.36–1.07)	0.084
Melanoma	1.63 (1.07–2.46)	0.022
RCC	0.45 (0.19–1.09)	0.077
ECOG	1.55 (1.24–1.94)	<0.001
Extracranial metastasesb	1.20 (1.06–1.37)	0.005
Intracranial metastasesc	0.89 (0.63–1.27)	0.526
Systemic disease status	2.36 (1.59–3.52)	<0.001
History of cranial surgery	0.59 (0.37–0.94)	0.025
History of WBRT	0.86 (0.58–1.24)	0.425
Past medical history
Cardiac	2.06 (1.25–3.41)	0.005
Vascular	1.87 (1.23–2.83)	0.004
Infectious	3.53 (1.05–11.9)	0.042
Neurological exam
Motor deficit	1.12 (0.70–2.01)	0.515
Vision loss	1.36 (0.60–3.10)	0.459
Any neurological deficit	1.48 (1.01–2.15)	0.043

^aOdds ratio is compared to a baseline of NSCLC.

^bOR is for every additional independent system with active metastatic disease.

^cMedian number for series was two metastases, treated as over/under two metastases or oligometastases versus multiple metastases.