Figure 6.

Diabetes-free survival in female Ins2^−/− NOD mice immunized with CCGAD65 peptide. In conventional animal facilities, 4-week-old female Ins2^−/− NOD mice received four weekly subcutaneous injections of 50 μg of CCGAD65 (n = 11) or AAGAD65 (n = 10) or CCHEL (n = 8) peptide in alum as indicated. Control group (n = 11) remained untreated. Blood glucose levels were monitored weekly up to 20 weeks of age. Vertical axis represents percentage of diabetes-free survival. Results from two independent experiments, *P < 0.05, **P < 0.005 (Mantel–Cox log-rank test).