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. 2016 Mar 2;7:70. doi: 10.3389/fphys.2016.00070

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Copyright © 2016 Bloch-Zupan, Huckert, Stoetzel,Meyer, Geoffroy, Razafindrakoto, Ralison, Randrianaivo, Ralison, Andriamasinoro, Ramanampamaharana, Randrianazary, Ralimanana, Richard, Gorry, Manière, Rasoamananjara, Rakoto Alson and Dollfus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical description of the disease. (A) The remote village of Antananarivo. (B–J) Inhabitants'dentition showing the typical features of dentinogenesis imperfecta with the gray-brown discolouration of the dentin clearly visible after enamel cleavage and progressive tooth wear. (C) On the retro-alveolar radiography of the lower right premolar/molar sector of individual (B), cervical constriction, short roots and the disappearance of pulp spaces due to erratic dentin formation represent the characteristic hallmarks of dentinogenesis imperfecta. (H–J) In addition to dentin anomalies, hypoplastic enamel defects exist, with the presence of pits, striae and flattened buccal surfaces.