Table 1.

Lipid profile of mice fed a HFD and HFD supplemented with CA

	WT	Ucpl-KO	WT + CA	Ucp1-KO + CA
TAG, mmol/l	0.77 ± 0.03	0.98 ± 0.17	0.84 ± 0.04	1.08 ± 0.13
TC, mmol/l	4.66 ± 0.28	4.36 ± 0.26	3.89 ± 0.28	3.80 ± 0.12
HDL, mmol/l	2.32 ± 0.05	2.21 ± 0.09	1.28 ± 0.34	2.03 ± 0.11
Non-HDL, mmol/l	2.34 ± 0.26	2.15 ± 0.0.18	2.59 ± 0.52	1.77 ± 0.08
ALT, U/l	33.48 ± 4.72	28.98 ± 5.15	171.4 ± 52.54	57.62 ± 14.40

Data are presented as means ± SE; n = 5–6.

HFD, high-fat diet; CA, cholic acid; WT, wild type; Ucpl, uncoupling protein 1; KO, knockout; TAG, triacylglycerol; TC, total cholesterol; ALT, alanine transaminase.

Plasma levels of TAG, TC, HDL, and non-HDL are the difference between TC and HDL and ALT. Differences between groups were analyzed by 2-way ANOVA with Bonferroni’s multiple test.