Fig. 7.

Effects of increasing concentrations of 2-ME and 17β-estradiol on LPS-induced (1 μg/ml for 90 min) phagocytosing activity in microglia. Top: representative photomicrographs depicting the concentration-dependent (1-1,000 nmol/l) inhibition of phagocytosis by 2-ME. Bar graphs depict the comparative effects between 2-ME, 2-OE, 17β-estradiol, and 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN) on phagocytosis. In contrast to 2-ME, 17β-estradiol and DPN were unable to inhibit phagocytosis by activated microglia under identical conditions. Results are presented as means ± SE (n = 3). *P < .05 vs. LPS-treated cells.