Table 1.

History of islet pathology in human diabetes reported as original publications

1869	Langerhans P. Discovery of pancreatic islets, Thesis, Gustav Lange1
1893	Laguesse E. Named islet of Langerhans, Comp Rend Soc Biol 5: 622, 1893
1889	von Mering, Minkowski O. Canine diabetes after pancreatectomy. Zbl Klin Med 10: 393, 1889
1901	Opie EL. Hyaline changes in the islet of diabetes3
1921	Banting FG, Best CH. Discovery of insulin2
1956	Mclean N, Ogilvie RF. Islet area reduction in diabetes10
1965	Gepts W. Insulitis in type 1 diabetes (Pathologic anatomy of the pancreas in human diabetes. Diabetes 14: 619–633, 1965)
1977	Saito K et al. Reduced islet area in type 1 and type 2 diabetes but no alteration of cell composition11
1982	Stefan Y et al. No significant islet changes in European type 2 diabetes36
1983	Rahier J et al. No significant changes in β cells in European type 2 diabetes37
1987	Westermark P, Cooper GJ. Discovery of amylin in the hyalinized islets (Westermark P et al. Proc Natl Acad Sci USA 84: 3881–3885, 1987. Cooper GJ et al. Proc Natl Acad Sci USA 84: 8628–8632, 1987)
2002	Sakuraba H et al. Reduction of β cell mass in Japanese type 2 diabetes31
2003	Butler A et al. Reduction of β cell volume density in American type 2 diabetes and subjects with impaired fasting glucose39
2003	Yoon KH et al. Reduction of β cell volume density and increase in α cell volume density in Korean type 2 diabetes38
2007	Ehses JA et al. Inflammation in the islet of type 2 diabetes. (Ehses JA et al. Diabetes 56: 2356–2370, 2007)
2007	Rahier J et al. Reduction of β cell volume density in European type 2 diabetes40
2007	Henquin JC, Rahier J. Increase in α cell mass in European type 2 diabetes47
2014	Mezza T et al. Transdifferentiation of islet endocrine cells in IGT49
2014	Mizukami H et al. Involvement of oxidative stress, ER‐stress, and autophagy deficits in type 2 diabetic islets24