Fig. 1.

QIBA DCE-MRI digital reference object (DRO) image. DRO v.8 consists of 30 $10\times 10\text{pixel}$ patches with different combinations of $K^{\mathrm{trans}}$ and $v_{\mathrm{e}}$. Total time of imaging is 6 min, which results in 90 timepoints for the 4 s temporal resolution. (a) $K^{\mathrm{trans}}$ distribution over the phantom, increasing from top to bottom from 0.01 to $0.35{\min }^{-1}$. (b) Simulated MRI intensity signal time courses corresponding to the rightmost column of the DRO with fixed $v_{\mathrm{e}}=0.5$ and varying $K^{\mathrm{trans}}$ values 0.01, 0.02, 0.05, 0.1, 0.2, and $0.35{\min }^{-1}$. (c) $v_{\mathrm{e}}$ distribution over the DRO increasing from left to right. (d) MRI intensity signal time courses for the bottom row of the DRO with fixed $K^{\mathrm{trans}}=0.35{\min }^{-1}$ and $v_{\mathrm{e}}$ values 0.01, 0.05, 0.1, 0.2, and 0.5.