Fig. 5.

Sensitivity of PCa DCE-MRI PK analysis to the bolus arrival delay. PK parameters’ sensitivity within the TROI to the choice of ${\mathrm{BAT}}_{\mathrm{TRF}}$ for PCa patient #2. BAT_AIF was measured automatically from the AIF concentration curve and the BAT_AIF index was set manually in seven consecutive tests. (a) Illustration of the measured AIF from image (red dotted line), the mean (blue solid line) ± maximum/minimum (light blue solid area) for 104 TRF concentration curves in the tumor tissue ROI. (b) 2-D axial image showing delineated ROIs for AIF and tissue ROI on DCE-MRI image (the tissue ROI continues in two adjacent axial planes). (c–e) boxplots of (c) $K^{\mathrm{trans}}$, (d) $v_{\mathrm{e}}$ and (e) $R^2$ at different delay timepoints (timepoint unit: DCE-MRI $\text{sampling rate}=4.4\mathrm{s}$).