Fig. 7.

Percent of voxels with good fit and feasible ${\mathrm{BAT}}_{\mathrm{TRF}}$ range in PCa patients. PK modeling was performed voxel-wise using ${\mathrm{BAT}}_{\mathrm{TRF}}$ measured by four methods: LL, PL, OQ and PG. The plots show the voxels in which the fit satisfied Eq. (8) with $\tau ={\mathrm{BAT}}_{\text{AIF}}+20\mathrm{ts}$ for two groups of ROIs: (a) tumor and (b) whole prostate gland. LL appeared to result in the largest number of the voxels that did not meet the validity criteria, whereas considerable variability in the number of such voxels was observed among the remaining BAT estimation methods. Note that in the case of patients 1, 14, and 15, the LL method did not result in valid voxels within the TROI.