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. 2016 Feb 20;8(2):25. doi: 10.3390/cancers8020025

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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The mRNA expression levels of inducible inflammation-related enzymes and pro-inflammatory cytokines in colorectal tissue samples from mice treated with DSS with or without Hrh antagonists. Total RNA was extracted from the colorectal tissues of untreated and DSS/antagonists-treated mice. The mRNA levels of (A) COX-2, (B) iNOS, (C) TNF-α, (D) IL-1β and (E) IL-6 were measured by quantitative RT-PCR. Treatment with cimetidine or clobenpropit in the diet significantly decreased the mRNA expression of all molecules (* p < 0.05). The expression was normalized to the β-actin mRNA expression level. The data are expressed as the means ± SD from three independent assays (n=8 from each group). The ordinates show the relative mRNA expression (/β-actin).