Table 3.
Meta-analysis Result for PSCA rs2294008 C > T polymorphism.
| Variables | N | Case/Control | T vs. C Allele | TT vs. CC | CT vs. CC | CT + TT vs. CC | TT vs. CC + CT | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | |||
| All | 28 | 17,479/19,799 | 1.16 (1.07–1.25) | 0.000 | 0.000/79.335 | 1.28 (1.10–1.50) | 0.002 | 0.000/74.804 | 1.21 (1.09–1.34) | 0.000 | 0.000/75.122 | 1.24 (1.11–1.39) | 0.000 | 0.000/80.158 | 1.17 (1.05–1.30) | 0.005 | 0.000/60.832 |
| Ethnicity | |||||||||||||||||
| Caucasian | 8 | 2135/4184 | 1.20 (0.99–1.45) | 0.053 | 0.000/79.874 | 1.45 (1.02–2.08) | 0.040 | 0.000/78.000 | 1.03 (0.75–1.40) | 0.877 | 0.000/78.481 | 1.16 (0.84–1.60) | 0.373 | 0.000/82.426 | 1.46 (1.28–1.66) | 0.000 | 0.120/38.884 |
| Asian | 20 | 15,344/15,615 | 1.14 (1.05–1.24) | 0.002 | 0.000/79.288 | 1.22 (1.03–1.45) | 0.020 | 0.000/73.249 | 1.27 (1.14–1.41) | 0.000 | 0.000/74.134 | 1.27 (1.13–1.43) | 0.000 | 0.000/80.253 | 1.08 (0.96–1.22) | 0.262 | 0.001/57.234 |
| Cancer type | |||||||||||||||||
| BC | 4 | 2386/4250 | 1.21 (1.12–1.32) | 0.000 | 0.992/0.000 | 1.39 (1.14–1.69) | 0.001 | 0.873/0.000 | 1.37 (1.21–1.54) | 0.000 | 0.576/0.000 | 1.36 (1.22–1.53) | 0.000 | 0.689/0.000 | 1.12 (0.945–1.33) | 0.192 | 0.848 /0.000 |
| GC | 16 | 11,483/10,882 | 1.21 (1.09–1.35) | 0.000 | 0.000/83.251 | 1.45 (1.16–1.78) | 0.001 | 0.000/80.616 | 1.30 (1.16–1.45) | 0.000 | 0.000/62.932 | 1.36 (1.19–1.55) | 0.000 | 0.000/76.780 | 1.25 (1.07–1.47) | 0.007 | 0.000/72.933 |
| Other Cancer | 8 | 3610/4667 | 0.96 (0.90–1.03) | 0.291 | 0.218/26.402 | 0.95 (0.81–1.11) | 0.481 | 0.321/13.908 | 0.90 (0.72–1.11) | 0.312 | 0.013/60.713 | 0.92 (0.75–1.11) | 0.383 | 0.019/58.256 | 1.02 (0.89–1.17) | 0.765 | 0.552/0.000 |
Significant associations are shown in bold, ph—p value of Q test for heterogeneity, OR—Odds Ratio, CI—Confidence Interval.