Table 4.
Meta-analysis Result for PSCA rs2976392 G > A polymorphism.
| Variables | N | Case/Control | A vs. G Allele | AA vs. GG | GA vs. GG | GA + AA vs. GG | AA vs. GG + GA | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | OR (95% CI) | p | ph/I2 | |||
| All | 11 | 5970/5707 | 1.09 (0.95–1.25) | 0.210 | 0.000/81.116 | 1.10 (0.82–1.48) | 0.654 | 0.000/78.184 | 1.13 (0.98–1.31) | 0.087 | 0.004/61.549 | 1.161 (0.93–1.33) | 0.256 | 0.000/77.837 | 1.04 (0.82–1.32) | 0.756 | 0.000/73.621 |
| Ethnicity | |||||||||||||||||
| Caucasian | 2 | 431/614 | 1.39 (0.77–2.51) | 0.281 | 0.001/90.899 | 1.90 (0.60–6.03) | 0.276 | 0.001/90.399 | 1.20 (0.57–2.54) | 0.639 | 0.020/81.566 | 1.22 (0.36–4.19) | 0.753 | 0.000/94.07 | 1.66 (0.88–3.13) | 0.120 | 0.024/80.307 |
| Asian | 9 | 5053/4612 | 1.04 (0.91–1.19) | 0.540 | 0.000/76.841 | 0.981 (0.75–1.28) | 0.891 | 0.001/69.334 | 1.13 (0.98–1.31) | 0.100 | 0.008/61.119 | 1.10 (0.94–1.30) | 0.242 | 0.000/71.634 | 0.93 (0.75–1.16) | 0.529 | 0.010/60.305 |
| Cancer type | |||||||||||||||||
| GC | 7 | 5087/4524 | 1.14 (0.95–1.38) | 0.165 | 0.000/87.766 | 1.16 (0.76–1.77) | 0.498 | 0.000/86.220 | 1.21 (1.02–1.43) | 0.026 | 0.003/69.157 | 1.22 (0.99–1.50) | 0.066 | 0.000/82.190 | 1.04 (0.73–1.48) | 0.829 | 0.000/82.477 |
| Other Cancer | 4 | 873/1183 | 1.02 (0.90–1.16) | 0.264 | 0.428/0.000 | 1.05 (0.82–1.35) | 0.713 | 0.000/0.520 | 0.91 (0.74–1.14) | 0.419 | 0.676/0.000 | 0.87 (0.71–1.07) | 0.189 | 0.210/33.715 | 1.10 (0.89–1.36) | 0.365 | 0.349/8.804 |
Significant associations are shown in bold, ph—p value of Q test for heterogeneity, OR—Odds Ratio, CI—Confidence Interval.