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. 2016 Mar 2;6:22525. doi: 10.1038/srep22525

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Copyright © 2016, Macmillan Publishers Limited

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(a) Correlation profile of 109 plasma significant metabolites and 160 urine significant metabolites among CHD samples and control subjects were performed by spearman correlation analysis with Cytoscape software. All these annotated metabolites were distributed by their engaged pathways and metabolisms: lipids metabolism showed significantly negatively correlations with microbial related metabolism. Ellipses were plasma metabolites, round rectangles were urine metabolites. Yellow lines : 0.9 > rho ≥ 0.5, Green lines : rho ≤ −0.5. (b) Veen diagram of all significant differential metabolites in plasma and urine showed there are 7 common significantly changed metabolites. (c) Spearman correlation analysis of 7 metabolites in plasma. (d) Spearman correlation analysis of 7 metabolites in urine.