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. 2016 Jan 26;5(2):16. doi: 10.3390/jcm5020016

Figure 4.

Figure 4

Effects of LPAR antagonists on breast cancer cell proliferation. Serum-starved MCF-7 (A) or MDA-MB-231 (B) cells were incubated with or without 10 µM LPA or 10 nM EGF in the absence and presence of 10 µM AM966 or 10 µM Ki16425. Each data point represents the mean ± SEM (n = 4) of values (number of live cells per well) from two separate experiments, each performed with two separate replicate wells of cells for each experimental condition (**** p < 0.0001 compared to control). The 48-h time is point shown; similar results were obtained at 24 and 72 h. Data analysis was performed using two-way ANOVA, followed by Tukey’s multiple comparisons test.