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Differential eicosanoid metabolism from omega-6 and omega-3 FA sources. Arachidonic acid, 20:4n-6 (AA), is metabolized via lipoxygenase and cyclooxygenase pathways. Eicosapentaenoic acid, 20:5n-3 (EPA) acts as a competitive inhibitor to the cyclooxygenase enzyme complex with AA and produces different leukotriene and prostaglandin oxidation products. Malondialdehyde (MDA) is a product of prostaglandin and thromboxane metabolism and is commonly used as a measure of lipid peroxidation.
