Figure 1.

Time courses of cold and mechanical allodynia induced by a single injection of oxaliplatin in mice. (a,b) Behavioral tests for cold and mechanical allodynia were performed before (day point zero) and after the administration of oxaliplatin (6 mg/kg, i.p.). 5% glucose was used as control and was injected intraperitoneally. Cold and mechanical allodynia were assessed by the acetone and von Frey filament tests, respectively. Data are presented as the mean ± S.E.M. for 8 mice; *** p < 0.001 vs. 5% glucose, by unpaired t-test.