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CCR2 inhibition decreased production of inflammatory chemokines. Expression is shown of Ccl2, Ccr2, RANTES (Ccl5), Tnfα, Il-6, Il-10, Il-12, and Tgfβ1 as assessed by RT-PCR in the stenotic kidney of mice with sham surgery (n = 5 mice) or mice with RAS surgery that were either treated with CCR2 inhibitor (RS-102895; n = 9 mice) or vehicle (water; n = 12 mice). Values are means ± SE normalized against 18S transcript and expressed as fold-increase relative to sham expression.
