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. 2015 Sep 14;526(7571):82–90. doi: 10.1038/nature14962

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© The Author(s) 2015

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-sa/3.0.

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Extended Data Figure 3 — Derived allele frequency (DAF) spectrum for UK10K-cohorts chromosome 20 variants divided by functional class. a, Proportion of total variants (standardized across DAF bins) as a function of DAF for different genic elements. b, Standardized proportion of all variants by DAF bin, and divided into conserved (GERP > 2) versus neutral (GERP ≤ 2) sites. c, Ratio of conserved versus neutral variants by DAF bin, and classified by chromatin segmentation domains defined by ENCODE as detailed in the methods.