Extended Data Figure 2. HAV capsid protein structure.
a,c, Stereo diagrams showing the structures of the capsid proteins VP1, VP2 and VP3, respectively. The Cα backbone is shown as a thin line, the N and C termini are labeled, every 10th residue is marked with a small sphere and every 20th is numbered. d, VP1 is initially produced with an 8 kD C-terminal extension (known as PX) unique to HAV among picornaviruses. PX is cleaved from the full particle by an unknown host protease. According to the data shown in Extended Data Figure 1 and the electron density maps, the particles we have analysed do not contain PX, but if it were present we would expect its course to start at the purple positions (C-termini of VP1) on the surface of the virus.