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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Neurobiol Aging. 2015 Dec 2;39:90–98. doi: 10.1016/j.neurobiolaging.2015.11.013

Figure 4. Ts2 mice develop neuronal endosomal pathology preceding cholinergic neurodegenerative changes.

Figure 4

Quantitative analysis revealed that ChAT-positive MSN numbers remain unchanged in 4 month old Ts2 mice compared to 2N mice (Fig. A, B). Representative neurons labeled with anti-rab5 antibody are shown in the MSN (C-F) and cingulate cortex (G, H) 4 month old 2N and Ts2 mice. Rab5-positive early endosomes are enlarged in Ts2 mice (F, H inset) compared to 2N (E, G inset). Increased rab5-positive endosome numbers and sizes are seen in mice from 4 months old to 16 months of age (I, J, n=9-10, for each genotype and age group) (*, p<0.05, **, p<0.01). Graphs show mean ± SEM.

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