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. 2016 Mar 2;6:22298. doi: 10.1038/srep22298

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(a) CD spectra of c-Myc_370–409 with indicated concentrations of PKUMDL-YC-1205 (left) and dose-response curve at 196 nm (right). The apparent K_d of PKUMDL-YC-1205 was 61.8 ± 0.7 μM, as predicted by the Hill equation. (b) SPR direct binding curves of the indicated concentrations of PKUMDL-YC-1205 (left). The K_d value was 18 ± 12 μM based on affinity fitting of the dose-response curve (right). Data represent the mean ± standard deviation of three independent experiments.