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. 2016 Mar 2;6:22298. doi: 10.1038/srep22298

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Copyright © 2016, Macmillan Publishers Limited

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(a) Growth inhibition of HL-60 cells by PKUMDL-YC-1205 was assessed by the MTT assay after exposure to indicated concentrations of PKUMDL-YC-1205 for 72 hours. The EC₅₀ was 40.0 ± 1.9 μM. (b) Percentage of HL-60 cells in different phases of the cell cycle after treatment with 17.8 μM, 26.7 μM, and 40.0 μM PKUMDL-YC-1205 for 24 hours. Data represent the mean ± standard deviation of three independent experiments. (c) c-Myc mediated transcriptional activity in HL-60 cells was blocked. Data represent the mean ± standard error of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.005.